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Sponsors and Collaborators: |
University of Edinburgh University of Aarhus University of Oxford |
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Information provided by: | University of Edinburgh |
ClinicalTrials.gov Identifier: | NCT00789451 |
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
Condition | Intervention |
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Ischaemic Heart Diseases |
Procedure: Forearm vascular study |
Study Type: | Interventional |
Study Design: | Basic Science, Randomized, Double Blind (Investigator, Outcomes Assessor), Placebo Control, Crossover Assignment |
Official Title: | The Effect of Ischaemic-Reperfusion on the Endogenous Fibrinolysis in Man |
Estimated Enrollment: | 12 |
Study Start Date: | August 2008 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Sham Comparator
no ischaemia - only sham. Blood pressure cuff inflation up till 10 mmHg on the upper arm for 20 mins.
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Procedure: Forearm vascular study
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of substance P (2,4,8 pmol/min). Venous blood sampling via cannula in antecubital fossa.
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2: Active Comparator
Ischaemia 20 minutes. Blood pressure cuff will be inflated around the upper arm for 20 minutes to induce ischaemia.
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Procedure: Forearm vascular study
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of substance P (2,4,8 pmol/min). Venous blood sampling via cannula in antecubital fossa.
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Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Christian M Pedersen, MD | +441312426437 | Christian.M.Pedersen@ed.ac.uk |
United Kingdom | |
University of Edinburgh, 49 Little France Crescent | Recruiting |
Edinburgh, United Kingdom, EH16 4SB | |
Principal Investigator: Christian M Pedersen, MD | |
Sub-Investigator: Nick Cruden, MD, PhD | |
Sub-Investigator: David E Newby, PhD, FRCP | |
Sub-Investigator: Rajesh K Kharbanda, MD, PhD | |
Sub-Investigator: Gareth Barnes, MD |
Study Director: | David E Newby, PhD, FRCP | University of Edinburgh |
Study Director: | Rajesh K Kharbanda, PhD, FRCP | University of Oxford |
Responsible Party: | University of Edinburgh ( Christian M Pedersen, clinical research fellow ) |
Study ID Numbers: | CMP 1 |
Study First Received: | November 10, 2008 |
Last Updated: | November 10, 2008 |
ClinicalTrials.gov Identifier: | NCT00789451 |
Health Authority: | United Kingdom: Research Ethics Committee |
Ischaemia reperfusion t-PA Fibrinolysis Endothelial function |
Heart Diseases Myocardial Ischemia Vascular Diseases |
Tissue Plasminogen Activator Ischemia Substance P |
Pathologic Processes Cardiovascular Diseases |