Inclusion Criteria:

• Primary complaint includes one of the following symptoms: chronic cough (dry, hacking, or nocturnal), hoarseness, sore throat, globus sensation, or throat clearing. These symptoms will be identified by a yes response to SRQ (Appendix 7) items 2, 3, 4, 5, 6, and 8. Furthermore, symptom(s) must be chronic (present for at least 1 month), and recurrent (at least twice per week). These criteria correspond to SRQ columns on page 3-5. The first column asks: When in your life did you first notice this symptom? A response with either number 2, 3, 4, or 5 meets criteria for chronic. The second column asks: How frequently have you noticed the symptom? A response with either number 3, 4, or 5 meets criteria for recurrent.

Exclusion Criteria:

• History of head and neck cancer/radiation/surgery (SRQ items 15, 16, 17)
• History of esophagus/stomach surgery (SRQ item 22)
• Peptic or duodenal ulcer disease; stomach or gastric ulcer disease; history of esophageal stricture, or Barrett's esophagus, or esophagitis, or tumor of the esophagus or stomach (SRQ item 23 and review of electronic surgical records of Mayo Clinic patients)
• Presence of alarm symptoms (hemoptysis, unexplained loss of 10 or more pounds in the past 3 months), obtained from Appendix 5 for Community Subjects, medical record for clinic subjects. History of dysphagia, defined as a yes answer to SRQ item 7.
• PPI use within 4 weeks, obtained from Appendix 5 for Community Subjects, medical record for clinic subjects
• Use of warfarin or digoxin, obtained from Appendix 5 for Community Subjects, medical record for clinic subjects
• Pregnancy at the time of enrollment, based on urine pregnancy test
• Inability to understand or read English at a 6th grade level
• Residence outside of the United States of America (USA)
• Age younger than 18 years old