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Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism
This study is currently recruiting participants.
Verified by Mount Sinai School of Medicine, April 2007
Sponsored by: Mount Sinai School of Medicine
Information provided by: Mount Sinai School of Medicine
ClinicalTrials.gov Identifier: NCT00211783
  Purpose

This study investigates face processing, response inhibition and phoneme processing in autistic adults by fMRI.


Condition Intervention
Autism
Asperger's Syndrome
Procedure: fMRI

MedlinePlus related topics: Asperger's Syndrome Autism
U.S. FDA Resources
Study Type: Observational
Study Design: Prospective
Official Title: fMRI for the Study of Response Inhibition, and Face and Linguistic Processing in Autism

Further study details as provided by Mount Sinai School of Medicine:

Estimated Enrollment: 30
Study Start Date: November 2004
Detailed Description:

Fifteen adult outpatients with high functioning autism or Asperger's Syndrome will be recruited. Fifteen healthy volunteers matched for age and IQ will also be recruited. Participants will undergo an fMRI scan. During the scan they will perform a task. The paradigm is designed to test control inhibition, face processing and language. Therefore, it includes a go-no go test, a face emotion discrimination test and a linguistic sound. The subjects are shown a series of faces with happy or sad expressions in random order. Each face presentation is accompanied by either a standard or variant sound. The sound stimulus is the English phoneme /oe/. The variant sound was created by raising the frequency of the standard sound by 20%. The task consists of four blocks. During each block the subjects are asked to press a button when they see a happy or sad face depending on the block. Each block consists of 96 trials lasting 2 seconds and an initial and final fixation period of 40 sec. For each trial the target image is projected for 500 ms. There is 1250 ms fixation time allowed for response and 250 ms for jitter. Twenty-four of the 96 trials are no go trials and 16/96 are sound oddball trials. The oddball is at least two trials apart (between two variant sounds there are at least two standard sounds). There are 24 faces displayed in total, 12 female and 12 male. Faces switch every 16 trials. Face genders are balanced. The faces were selected with over 80% congruency except for two faces with congruency of over 72%. The correlation between sound (2 conditions: standard versus variant) and target condition (go-no go) is zero. The task was piloted on healthy controls and autistic adults. All subjects performed well.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age range of 18-50 years old
  • Diagnosis: autism spectrum disorder by Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) and Autism Diagnostic Interview - Revised (ADI-R)
  • Intelligence quotient (IQ) > 80
  • Outpatients

Exclusion Criteria:

  • Subjects with epilepsy
  • Subjects with history of schizophrenia, schizoaffective disorder or other Axis 1 mental disorders, such as bipolar disorder
  • Subjects reporting history of encephalitis, phenylketonuria, tuberous sclerosis, fragile X syndrome, anoxia during birth, neurofibromatosis, hypomelanosis of Ito, hypothyroidism, Duchenne muscular dystrophy, and maternal rubella
  • Subjects who have received depot neuroleptic medication, or other psychoactive drugs within the past 5 weeks.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00211783

Contacts
Contact: Evdokia Anagnostou 212-241-4229 evdokia.anagnostou@mssm.edu
Contact: Kate Stamper 212-241-7098 katherine.stamper@mssm.edu

Locations
United States, New York
Mount Sinai School of Medicine Recruiting
New York, New York, United States, 10029
Contact: Evdokia Anagnostou     212-241-4229        
Sponsors and Collaborators
Mount Sinai School of Medicine
Investigators
Principal Investigator: Evdokia Anagnostou Mount Sinai School of Medicine
  More Information

Study ID Numbers: GCO# 04-0749
Study First Received: September 13, 2005
Last Updated: November 15, 2007
ClinicalTrials.gov Identifier: NCT00211783  
Health Authority: United States: Institutional Review Board

Keywords provided by Mount Sinai School of Medicine:
autism
fMRI
response inhibition
face processing
linguistic processing

Study placed in the following topic categories:
Developmental Disabilities
Child Development Disorders, Pervasive
Facies
Mental Disorders
Autistic Disorder
Mental Disorders Diagnosed in Childhood
Asperger Syndrome

Additional relevant MeSH terms:
Pathologic Processes
Disease
Syndrome

ClinicalTrials.gov processed this record on January 16, 2009