Multicenter Study of Silent Myocardial Ischemia (MSSMI) - Full Text View

Sponsored by:	National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:	National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:	NCT00005216

Purpose

To determine if silent myocardial ischemia was associated with an increased risk of cardiac mortality and morbidity during a one to three year follow-up in patients with coronary heart disease.

Condition
Cardiovascular Diseases Coronary Disease Myocardial Ischemia Heart Diseases Myocardial Infarction Angina, Unstable Arrhythmia

Genetics Home Reference related topics: Brugada syndrome short QT syndrome

MedlinePlus related topics: Angina Arrhythmia Coronary Artery Disease Heart Attack Heart Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:	April 1988
Estimated Study Completion Date:	December 1994

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Eligibility

Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

No Contacts or Locations Provided

More Information

Publications:

Moss AJ, Benhorin J. Prognosis and management after a first myocardial infarction. N Engl J Med. 1990 Mar 15;322(11):743-53. Review. No abstract available.

Bigger JT Jr, Hoover CA, Steinman RC, Rolnitzky LM, Fleiss JL. Autonomic nervous system activity during myocardial ischemia in man estimated by power spectral analysis of heart period variability. The Multicenter Study of Silent Myocardial Ischemia Investigators. Am J Cardiol. 1990 Aug 15;66(4):497-8. No abstract available.

Freedland KE, Carney RM, Krone RJ, Case NB, Case RB. Psychological determinants of anginal pain perception during exercise testing of stable patients after recovery from acute myocardial infarction or unstable angina pectoris. Am J Cardiol. 1996 Jan 1;77(1):1-4.

Bodenheimer MM, Wackers FJ, Schwartz RG, Brown M. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. Multicenter Myocardial Ischemia Research Group. Am J Cardiol. 1994 Dec 15;74(12):1196-200.

Krone RJ, Gregory JJ, Freedland KE, Kleiger RE, Wackers FJ, Bodenheimer MM, Benhorin J, Schwartz RG, Parker JO, Van Voorhees L, et al. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulatory patients several months after recovery from an acute coronary event: implications for management of stable coronary heart disease. Multicenter Myocardial Ischemia Research Group. J Am Coll Cardiol. 1994 Nov 1;24(5):1274-81.

Moss AJ, Goldstein RE, Hall WJ, Bigger JT Jr, Fleiss JL, Greenberg H, Bodenheimer M, Krone RJ, Marcus FI, Wackers FJ, et al. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA. 1993 May 12;269(18):2379-85.

Zareba W, Moss AJ, Raubertas RF. Risk of subsequent cardiac events in stable convalescing patients after first non-Q-wave and Q-wave myocardial infarction: the limited role of non-invasive testing. The Multicenter Myocardial Ischemia Research Group. Coron Artery Dis. 1994 Dec;5(12):1009-18.

Wackers FJ, Bodenheimer M, Fleiss JL, Brown M. Factors affecting uniformity in interpretation of planar thallium-201 imaging in a multicenter trial. The Multicenter Study on Silent Myocardial Ischemia (MSSMI) Thallium-201 Investigators. J Am Coll Cardiol. 1993 Apr;21(5):1064-74.

Moriel M, Benhorin J, Brown MW, Raubertas RF, Severski PK, Van Voohees L, Bodenheimer MM, Tzivoni D, Wackers FJ, Mass AJ. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The Multicenter Myocardial Ischemia Research Group. Am J Cardiol. 1996 Apr 15;77(10):798-804.

Goldstein RE, Andrews M, Hall WJ, Moss AJ. Marked reduction in long-term cardiac deaths with aspirin after a coronary event. Multicenter Myocardial Ischemia Research Group. J Am Coll Cardiol. 1996 Aug;28(2):326-30.

Narins CR, Zareba W, Moss AJ, Goldstein RE, Hall WJ. Clinical implications of silent versus symptomatic exercise-induced myocardial ischemia in patients with stable coronary disease. J Am Coll Cardiol. 1997 Mar 15;29(4):756-63.

Nakamura Y, Moss AJ, Brown MW, Kinoshita M, Kawai C. Differential effects of beta-blockers in patients after recovery from myocardial infarction and after recovery from unstable angina. Multicenter Myocardial Ischemia Research Group. Heart Vessels. 1997;Suppl 12:160-1.

Freedland KE, Nakamura Y, Carney RM, Case RB, Case NB, Kawai C, Krone RJ, Kato N, Kinoshita M. Angina pectoris after recovery from an acute coronary event--the role of psychological factors in Japanese vs North American patients. Jpn Circ J. 1997 Apr;61(4):299-307.

Nakamura Y, Kawai C, Moss AJ, Raubertas RF, Brown MW, Kinoshita M, Sasayama S, Nonogi H, Omae T, Tamaki S, Fujita M, Tanaka N, Hosoda S, Inoue H, Sugimoto T, Iinuma H, Kato K, Tamaki N, Sugiura N. Comparison between Japan and North America in the post-hospital course after recovery from an acute coronary event. Int J Cardiol. 1996 Aug;55(3):245-54.

Study ID Numbers:	1095
Study First Received:	May 25, 2000
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00005216
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Arterial Occlusive Diseases
Heart Diseases
Myocardial Ischemia
Angina Pectoris
Vascular Diseases
Pain
Arteriosclerosis
Ischemia
Chest Pain

Coronary Disease
Signs and Symptoms
Necrosis
Infarction
Myocardial Infarction
Angina, Unstable
Coronary Artery Disease
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009