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Sponsors and Collaborators: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
ClinicalTrials.gov Identifier: | NCT00005119 |
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country. Recent evidence has suggested that premenstrual syndrome (PMS) is associated with a calcium deficiency state and bone loss. This may place premenopausal women at greater risk for osteoporosis. An entity such as PMS may be an important physiological marker of a calcium disturbance. The purpose of this investigation is to understand more completely the extent to which calcium balance is disturbed in severe PMS or Premenstrual Dysphoric Disorder (PMDD) by utilizing new tools to assess calcium and bone turnover. The long term objective is to elucidate the pathophysiology of PMDD or severe PMS as it relates to calcium hormones and bone markers. The experimental design involves the comparison between women witn severe PMS and asymptomatic controls.
Condition | Intervention |
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Premenstrual Syndrome |
Procedure: Measures of calcium and bone turnover |
Study Type: | Interventional |
Study Design: | Diagnostic, Parallel Assignment |
Official Title: | Altered Calcium And Vitamin D Metabolism in PMDD |
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, New York | |
St. Luke's-Roosevelt Hospital | |
New York, New York, United States, 10019 |
Principal Investigator: | Susan Thys-Jacobs, MD | St.Luke's-Roosevelt Hospital- Columbia Presbyterian Medical Center |
Study ID Numbers: | STHYS-JACOBS, DK57869-01 |
Study First Received: | April 19, 2000 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00005119 |
Health Authority: | United States: Federal Government |
Premenstrual Dysphoric Disorder Severe Premenstrual Syndrome Calcium metabolism Vitamin D |
Bone Markers Premenopausal Menstrual Cycle |
Calcium, Dietary Vitamin D Menstruation Disturbances Ergocalciferols Premenstrual Syndrome |
Disease Pathologic Processes Growth Substances Vitamins Syndrome |
Physiological Effects of Drugs Bone Density Conservation Agents Micronutrients Pharmacologic Actions |