Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome

This study is ongoing, but not recruiting participants.

Sponsors and Collaborators:	National Center for Research Resources (NCRR) Oregon Health and Science University
Information provided by:	National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:	NCT00004343

Purpose

OBJECTIVES:

I. Determine whether Cushing's syndrome and stress-induced pseudo-Cushing's syndrome can be differentiated by evaluating endogenous corticotropin-releasing hormone activity.

Condition
Cushing's Syndrome

MedlinePlus related topics: Cushing's Syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening

Further study details as provided by National Center for Research Resources (NCRR):

Estimated Enrollment:	40
Study Start Date:	October 1999

Detailed Description:

PROTOCOL OUTLINE: Patients undergo a 30-hour infusion of deuterated cortisol with peripheral and petrosal vein measurements of adrenocorticotropin hormone (ACTH) and corticotropin-releasing hormone (CRH). Patients also have a 2-day, low-dose dexamethasone suppression test.

Patients with ACTH tumors are referred for pituitary surgery as indicated. Patients without Cushing's syndrome are entered as controls. During scheduled radiologic procedures, these subjects undergo ACTH and CRH sampling from the petrosal vein or cavernous sinus following a deuterated cortisol infusion.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

PROTOCOL ENTRY CRITERIA:

Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women Effective contraception required of fertile women

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004343

Locations

United States, Oregon
Oregon Health Sciences University
Portland, Oregon, United States, 97201-3098

Sponsors and Collaborators

National Center for Research Resources (NCRR)

Oregon Health and Science University

Investigators

Study Chair:

Mary H. Samuels

Oregon Health and Science University

More Information

Study ID Numbers:	NCRR-M01RR00334-0028, OHSU-3324
Study First Received:	October 18, 1999
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00004343
Health Authority:	United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

Cushing's syndrome
endocrine disorders
rare disease

Study placed in the following topic categories:

Hyperadrenalism
Rare Diseases
Cushing Syndrome
Adrenal gland hyperfunction
Adrenal Gland Diseases

Endocrine System Diseases
Stress
Endocrinopathy
Adrenocortical Hyperfunction

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome

ClinicalTrials.gov processed this record on January 16, 2009