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| Sponsored by: |
Kaohsiung Medical University Chung-Ho Memorial Hospital |
|---|---|
| Information provided by: | Kaohsiung Medical University Chung-Ho Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00769535 |
Purpose
Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls will be measured by PCR-RFLP or direct sequencing. The clinical relevance of patients will be compared in those with polymorphism and those without.
| Condition | Intervention |
|---|---|
|
Hepatocellular Carcinoma |
Genetic: Polymorphisms of HSP70 and TNF promoter |
| Study Type: | Interventional |
| Study Design: | Basic Science, Open Label, Uncontrolled, Single Group Assignment |
| Official Title: | Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma |
| Enrollment: | 600 |
| Study Start Date: | January 2000 |
| Study Completion Date: | June 2008 |
| Primary Completion Date: | June 2008 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
1: Experimental
Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls were measured with PCR_RFLP to assess their relationship with clinical relevance
|
Genetic: Polymorphisms of HSP70 and TNF promoter
To assess the relationship between clinical relevance and polymorphisms of HSP70 and tumor necrosis factor-alpha with PCR_RFLP
|
Heat shock protein 70 (HSP 70) may be involved in various aspects of immune system including infection, autoimmunity, and tumor immunity. The relationship between HSP70 expression, disease activity and cancer prognosis varied according to type of cancer. The overexpression of HSP70 by tumor cells contributes to tumor behavior. HSP70 is present in normal and abnormal hepatocytes, and was reported to be over-expressed in both hepatoma cell lines and human hepatocellular carcinoma (HCC) tissue. Recent study indicated that HSP70 is a molecular marker during early hepatocarcinogenesis. It is also involved in anti-tumor immunity in HCC.We also investigate the polymorphism of tumor necrosis factor-alpha promoter, and correlated to clinical relevance.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Taiwan | |
| Kaohsiung Medical University | |
| Kaohsiung, Taiwan, 807 | |
| Kaohsiung Medical University | |
| Kaohsiung, Taiwan, 807 | |
| Kaohsiung Medical University | |
| Kaohsiung, Taiwan, 807 | |
| Taiwan, Kaohsiun | |
| Kaohsiung Medical University | |
| Kaohsiung, Kaohsiun, Taiwan, 807 | |
| Principal Investigator: | Jung-Fa Tsai, M.D., Ph.D. | Professor of Medicine |
More Information
| Responsible Party: | Jung-Fa Tsai, Professor of Medicine, Kaohsiung Medical University ( Kaohsiung Medical University ) |
| Study ID Numbers: | KMUH-IRB-930047 |
| Study First Received: | February 26, 2008 |
| Last Updated: | October 7, 2008 |
| ClinicalTrials.gov Identifier: | NCT00769535 |
| Health Authority: | Taiwan: Department of Health |
|
heat shock protein70 tumor necrosis factor-alpha promoter polymorphism |
|
Liver Diseases Digestive System Neoplasms Carcinoma, Hepatocellular Liver neoplasms Carcinoma Liver Neoplasms Necrosis |
Digestive System Diseases Shock Gastrointestinal Neoplasms Adenocarcinoma Neoplasms, Glandular and Epithelial Hepatocellular carcinoma |
|
Neoplasms Neoplasms by Site Neoplasms by Histologic Type |
