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Sponsors and Collaborators: |
University of Heidelberg Swiss Federal Institute of Technology |
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Information provided by: | University of Heidelberg |
ClinicalTrials.gov Identifier: | NCT00773565 |
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.
Condition | Intervention |
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Obesity |
Dietary Supplement: Optifast |
Study Type: | Interventional |
Study Design: | Basic Science, Open Label, Single Group Assignment |
Estimated Enrollment: | 40 |
Study Start Date: | October 2008 |
Estimated Study Completion Date: | October 2010 |
Estimated Primary Completion Date: | October 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Optifast
Patients included take part at a weight reduction programm over one year.
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Dietary Supplement: Optifast
Formula diet for twelve weeks combined with physical activity and behavioral therapy
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Gottfried Rudofsky, MD | 0049622156 ext 38620 | gottfried_rudofsky@med.uni-heidelberg.de |
Germany | |
University Hospital Heidelberg | Recruiting |
Heidelberg, Germany, 69115 | |
Contact: Gottfried Rudofsky, MD 0049622156 ext 38620 gottfried_rudofsky@med.uni-heidelberg.de |
Study Chair: | Christian Wolfrum, PhD | ETH Zürich |
Responsible Party: | University Hospital of Heidelberg ( Gottfried Rudofsky, MD ) |
Study ID Numbers: | EFSD-CRP-2008 |
Study First Received: | October 15, 2008 |
Last Updated: | October 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00773565 |
Health Authority: | Germany: Ethics Commission |
patients with obesity (BMI > 30 kg/m2) |
Body Weight Signs and Symptoms Obesity |
Nutrition Disorders Overweight Overnutrition |