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Sponsored by: |
Herlev Hospital |
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Information provided by: | Herlev Hospital |
ClinicalTrials.gov Identifier: | NCT00309660 |
Treatment with PPARgamma ligands have been shown to reduces intestinal inflammation in murine models of colitis. The aim of this study was to evaluate the effect of treatment with local PPARgamma ligand (rosiglitazone) in distal ulcerative colitis.The patients are treated with rosiglitazone enema, once a day, for fourteen days. Disease activity was assessed before and after treatment by endoscopical and clinical activity score.
Condition | Intervention | Phase |
---|---|---|
Ulcerative Colitis |
Drug: Rosiglitazone |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Gitte Pedersen | + 45 44883418 | gitped01@herlevhosp.kbhamt.dk |
Denmark | |
Dept. Gastroenterology C, Herlev University Hospital | Recruiting |
Herlev, Denmark, 2730 | |
Contact: Gitte Pedersen, MD +45 44883418 gitped01@herlevhosp.kbhamt.dk | |
Principal Investigator: Gitte Pedersen, MD |
Principal Investigator: | Jørn Brynskov, Ass. Prof. | Dept Gastroenterology C, Herlev University Hospital, 2730 Herlev, Denmark |
Study ID Numbers: | PPAR2005 |
Study First Received: | March 30, 2006 |
Last Updated: | September 20, 2006 |
ClinicalTrials.gov Identifier: | NCT00309660 |
Health Authority: | Denmark: Danish Medicines Agency |
PPARgamma ligand Rosiglitazone Enema |
Digestive System Diseases Gastrointestinal Diseases Ulcer Colonic Diseases Inflammatory Bowel Diseases |
Colitis, Ulcerative Intestinal Diseases Gastroenteritis Rosiglitazone Colitis |
Hypoglycemic Agents Pathologic Processes Physiological Effects of Drugs Pharmacologic Actions |