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Sponsored by: |
Medical University of Vienna |
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Information provided by: | Medical University of Vienna |
ClinicalTrials.gov Identifier: | NCT00431730 |
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral and peripheral vascular disease, including ocular diseases like age-related macular degeneration or diabetic retinopathy. Data of a recent study performed in the investigators lab revealed abnormal choroidal blood flow regulation in chronic smokers as compared to age-matched non-smoking subjects during isometric exercise. However, no information is yet available about the regulation of retinal vascular tone in habitual smokers.
Thus, in the current study, the investigators set out to investigate whether the regulation of retinal vessels diameters is affected in habitual smokers. It has been shown in several reports that stimulation with diffuse luminance flicker, increases retinal arterial and venous diameters, indicating for the ability of the retina to adapt to changing metabolic demands. In the current study we use this effect as a tool to investigate whether the flicker induced vasodilatation is affected in habitual smokers. This would indicate for an impaired vascular regulation process in smokers.
Condition | Intervention |
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Ocular Physiology Retina Blood Flow Velocity |
Procedure: flicker light stimulation |
Study Type: | Interventional |
Study Design: | Non-Randomized, Open Label, Uncontrolled, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers? |
Ages Eligible for Study: | 18 Years to 35 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Austria | |
Department of Clinical Pharmacology | |
Vienna, Austria, 1090 |
Principal Investigator: | Gabriele Fuchsjaeger-Mayrl, MD | Department of CLinical Pharmacology, Medical University of Vienna |
Responsible Party: | Department of Clinical Pharmacology, Medical University of Vienna ( Gabriele Fuchsjäeger-Mayrl ) |
Study ID Numbers: | OPHT-121203 |
Study First Received: | February 5, 2007 |
Last Updated: | July 1, 2008 |
ClinicalTrials.gov Identifier: | NCT00431730 |
Health Authority: | Austria: Agency for Health and Food Safety |