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Sponsored by: |
Seoul National University Bundang Hospital |
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Information provided by: | Seoul National University Bundang Hospital |
ClinicalTrials.gov Identifier: | NCT00431717 |
The purpose of this study is to compare the difference of diagnostic efficiency between coronary CT angiography and myocardial perfusion single photon emission computerized tomography in asymptomatic patients with type 2 diabetes mellitus.
Condition |
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Coronary Atherosclerosis Diabetes Mellitus |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Study Comparing Coronary Computed Tomography Angiography and SPECT to Detect Subclinical Coronary Atherosclerosis in Asymptomatic Diabetes |
Enrollment: | 116 |
Study Start Date: | November 2006 |
Study Completion Date: | September 2007 |
Primary Completion Date: | September 2007 (Final data collection date for primary outcome measure) |
Coronary artery disease (CAD) is the leading cause of death in patients with diabetes. Patients with diabetes are known to have silent myocardial ischemia more frequently than those without diabetes. Furthermore, CAD in patients with diabetes frequently manifested in advance stage, and morbidity and mortality are higher than those without diabetes. Early screening and treatment of CAD in asymptomatic patients with diabetes might reduce high morbidity and mortality.
Myocardial perfusion single photon emission computerized tomography (SPECT) is known as a gold standard method in detecting silent myocardial ischemia in asymptomatic patients with diabetes. Despite of the power of detecting myocardial ischemia functionally, there are limitations of SPECT in diagnosing subclinical coronary atherosclerosis anatomically. In recent advance in technology, coronary CT angiography (CTA) could detect subclinical coronary atherosclerosis. However, there is a paucity of information comparing the diagnostic power between SPECT and CTA.
Therefore in our study, we compare the difference of diagnostic efficiency between coronary CT angiography and myocardial perfusion single photon emission computerized tomography in asymptomatic patients with type 2 diabetes mellitus.
In this study, we will recruit asymptomatic patients with diabetes. At the time of enrollment, all patients will undergo two imaging studies (SPECT and CTA) within a few days apart. When patients had positive result in either study, they will undergo coronary angiography for confirmation. We will evaluate the results of two studies comparing with coronary angiography. When the patients are eligible for study, investigators will give information about the study and obtain written consent. The presence of chest pain symptom will be screened with Rose questionnaire. Medical history and physical examination will be performed, and baseline laboratory work-up will be performed. Investigators will evaluate the status of diabetic complication (retinopathy/nephropathy/cardiac autonomic neuropathy).
Ages Eligible for Study: | 50 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Asymptomtaic type 2 diabetes mellitus with multiple risk factors
Inclusion Criteria:
1)dyslipidemia, 2)hypertension, 3)smoking, 4)family history of premature coronary artery disease
Exclusion Criteria:
Korea, Republic of, Kyungki-do | |
Seoul National University Bundang hospital | |
Sungnam-si, Kyungki-do, Korea, Republic of |
Study Director: | Huk-Jae Chang, MD, PhD | Seoul National University Bundang Hospital |
Responsible Party: | Seoul National University Bundang Hospital ( Hyuk-Jae Chang MD, PhD ) |
Study ID Numbers: | B-0609/037-019 |
Study First Received: | February 5, 2007 |
Last Updated: | August 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00431717 |
Health Authority: | Korea: Food and Drug Administration |
Coronary Atherosclerosis Diabetes Mellitus |
Atherosclerosis Arterial Occlusive Diseases Heart Diseases Metabolic Diseases Myocardial Ischemia Diabetes Mellitus Vascular Diseases Endocrine System Diseases |
Arteriosclerosis Ischemia Coronary Disease Endocrinopathy Metabolic disorder Glucose Metabolism Disorders Coronary Artery Disease |
Cardiovascular Diseases |