Dr. Brinton's presentation highlighted the following:
Specific points included:
Dr. Toran-Allerand's presentation highlighted the following:
Dr. Gibbs's presentation highlighted the following:
Dr. Rapp's presentation addressed the following:
Dr. Morrison's presentation addressed the following research question: what is the behavioral impact of the observed synaptic effects of estrogen?
The wrap-up discussion about multiple processes involved changes in cognitive function and appropriateness of the ovariectomized animal model to human menopause. The following outline presents the topics included in this discussion:
Important Issues for Cognitive Function
I. Examples of Cognitive Testing in Memory and Attention With Hormone Therapy
Rats
Monkeys
II. Ovarian Hormones Affect Brain Neurobiology
III. Sites of Ovarian Hormone Actions in the Brain Relevant to Cognition
IV. Differences Between Natural Versus Surgical Menopause
Natural
Surgical
It is necessary to have better integrated communication between basic science and clinical investigators working on ovarian hormone therapy issues and its affects on cognition and the brain.
Earlier is better: waiting a long time before administering estrogen (10 years after loss of ovarian function) may result in the selective loss of function. This may be subtle and difficult to measure.
In advance of the meeting, Dr. Simpkins provided the following discussion points:
Dr. McEwen summarized Dr. Simpkin's work and addressed the following:
Dr. Finch's presentation highlighted the following:
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