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defined:
Replacement of one nucleotide in a DNA sequence by another nucleotide or replacement of one amino acid in a protein by another amino acid.
explained:
Listen to a detailed explanation. Dr. Leslie Biesecker, of the National Human Genome Research Institute's Laboratory of Genetic Disease Research, defines substitution.
illustrated:
View illustration
relatedterms:
amino acids, inherited, mutation, nucleotide, protein
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