Sanjay Awasthi , M.D.
Associate VP Clinical Research
Professor, Molecular Biology and Immunology
Department: Molecular Biology and Immunology
Office: EAD 408
Phone: 817-735-5482
Email: sawasthi@hsc.unt.edu

Education | Publications | Teaching | Funding | Memberships | Awards and Honors

Education
M.D. 1986 University of Texas Southwestern, Dallas TX Medicine
B.A. 1982 University of Texas at Austin, Austin TX Biochemistry

Publications

Awasthi YC, Sharma R, Yadav S, Dwivedi S, Sharma A, Awasthi S.  The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance. Curr Drug Metab. 2007 May; 8(4): 315-23.
PMID: 17504221 [PubMed - indexed for MEDLINE]

Awasthi S, Daverey A, Dwivedi A.  Modulation of AP-1 mediated estrogenic response by ormeloxifene in rat uterus. J Steroid Biochem Mol Biol. 2007 May; 104(3-5): 208-14.
PMID: 17553677 [PubMed - indexed for MEDLINE]

Singhal SS, Singhal J, Yadav S, Dwivedi S, Boor PJ, Awasthi YC, Awasthi S.  Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res. 2007 May; 67(9): 4382-9.
PMID: 17483352 [PubMed - indexed for MEDLINE]

Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ, Harrod R.  The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication. J Biol Chem. 2007 Apr; 282(16): 12048-57.
PMID: 17317667 [PubMed - indexed for MEDLINE]

Patibandla PK, Venkatesh V, Agarwal GG, Awasthi S, Husain N, Ahuja RC, Swastika S, Agarwal SK.  Effect of EDTA and ACD on blood storage for the detection of Plasmodium falciparum by PCR. J Vector Borne Dis. 2007 Mar; 44(1): 69-71.
PMID: 17378220 [PubMed - indexed for MEDLINE]

Singhal SS, Singhal J, Nair MP, Lacko AG, Awasthi YC, Awasthi S.  Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar; 30(3): 717-25.
PMID: 17273774 [PubMed - indexed for MEDLINE]

Yadav S, Zajac E, Singhal SS, Awasthi S.  Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Cancer Metastasis Rev. 2007 Mar; 26(1): 59-69.
PMID: 17260165 [PubMed - indexed for MEDLINE]

Awasthi S, Blesson CS, Dwivedi A.  Expression of oestrogen receptors alpha and beta during the period of uterine receptivity in rat: effect of ormeloxifene, a selective oestrogen receptor modulator. Acta Physiol (Oxf). 2007 Jan; 189(1): 47-56.
PMID: 17280556 [PubMed - indexed for MEDLINE]

Venkatesh V, Patibandla PK, Agarwal GG, Awasthi S, Ahuja RC, Nag VL, Kushwaha KP, Agarwal SK.  Performance characteristics of a rapid diagnostic test for malaria, when used to confirm cerebral malaria in children and young adults. Ann Trop Med Parasitol. 2007 Jan; 101(1): 85-7.
PMID: 17244413 [PubMed - indexed for MEDLINE]

Drake KJ, Singhal J, Yadav S, Nadkar A, Pungaliya C, Singhal SS, Awasthi S.  RALBP1/RLIP76 mediates multidrug resistance. Int J Oncol. 2007 Jan; 30(1): 139-44.
PMID: 17143522 [PubMed - indexed for MEDLINE]

Blesson CS, Awasthi S, Kharkwal G, Daverey A, Dwivedi A.  Modulation of estrogen receptor transactivation and estrogen-induced gene expression by ormeloxifene-a triphenylethylene derivative. Steroids. 2006 Nov; 71(11-12): 993-1000.
PMID: 16965798 [PubMed - indexed for MEDLINE]

Tammali R, Ramana KV, Singhal SS, Awasthi S, Srivastava SK.  Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin e2 production in human colon cancer cells. Cancer Res. 2006 Oct; 66(19): 9705-13.
PMID: 17018629 [PubMed - indexed for MEDLINE]

Nadkar A, Pungaliya C, Drake K, Zajac E, Singhal SS, Awasthi S.  Therapeutic resistance in lung cancer. Expert Opin Drug Metab Toxicol. 2006 Oct; 2(5): 753-77.
PMID: 17014393 [PubMed - indexed for MEDLINE]

Darmstadt GL, Kumar V, Yadav R, Singh V, Singh P, Mohanty S, Baqui AH, Bharti N, Gupta S, Misra RP, Awasthi S, Singh JV, Santosham M.  Introduction of community-based skin-to-skin care in rural Uttar Pradesh, India. J Perinatol. 2006 Oct; 26(10): 597-604.
PMID: 16915302 [PubMed - indexed for MEDLINE]

Singhal SS, Yadav S, Singhal J, Awasthi YC, Awasthi S.  Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76. Biochem Biophys Res Commun. 2006 Sep; 348(2): 722-7.
PMID: 16890208 [PubMed - indexed for MEDLINE]

Sharma A, Patrick B, Li J, Sharma R, Jeyabal PV, Reddy PM, Awasthi S, Awasthi YC.  Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis. Arch Biochem Biophys. 2006 Aug; 452(2): 165-73.
PMID: 16890185 [PubMed - indexed for MEDLINE]

Singhal SS, Wickramarachchi D, Singhal J, Yadav S, Awasthi YC, Awasthi S.  Determinants of differential doxorubicin sensitivity between SCLC and NSCLC. FEBS Lett. 2006 Apr; 580(9): 2258-64.
PMID: 16579994 [PubMed - indexed for MEDLINE]

Awasthi S, Cropper J.  Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells. Cell Immunol. 2006 Mar; 240(1): 31-40.
PMID: 16842767 [PubMed - indexed for MEDLINE]

Singhal SS, Awasthi YC, Awasthi S.  Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res. 2006 Feb; 66(4): 2354-60.
PMID: 16489041 [PubMed - indexed for MEDLINE]

Jain A, Kumar P, Awasthi S.  High ampicillin resistance in different biotypes and serotypes of Haemophilus influenzae colonizing the nasopharynx of healthy school-going Indian children. J Med Microbiol. 2006 Feb; 55(Pt 2): 133-7.
PMID: 16434703 [PubMed - indexed for MEDLINE]

Awasthi YC, Ansari GA, Awasthi S.  Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases. Methods Enzymol. 2005 Jan; 401(Pt 2): 379-407.
PMID: 16399399 [PubMed - indexed for MEDLINE]

SÄ?epanoviÄ? OR, Fitzmaurice M, Gardecki JA, Angheloiu GO, Awasthi S, Motz JT, Kramer JR, Dasari RR, Feld MS.  Detection of morphological markers of vulnerable atherosclerotic plaque using multimodal spectroscopy. J Biomed Opt. 2000 Jan; 11(2): 021007.
PMID: 16674182 [PubMed - indexed for MEDLINE]

Teaching
GENERAL CHEMISTRY, University of Texas, Arlington, 2003
ENZYMOLOGY, University of Texas, Arlington, spring 2005-2006
GRADUATE ADVISOR /MENTOR, 3 pre-doctoral students at present
GRADUATE COMMITTEE MEMBER, 5 pre-doctoral students at present

Funding
DHHS NIH 3 R01 CA77495 “Mechanism of Drug Transport in Lung Cancer Cells” 1998-2012, (PI)
DHHS NIH 1 R01 CA104661 “Role of RALBP1 in Xenobiotic and Radiation Resistance” 2004 – 2009,(PI)
DHHS NIH R15 “Dinuclear Ruthenium Complexes for Cancer Treatment” 2006- 2008 (co-PI)
Cancer Research Foundation of North Texas, “Diminished Drug Transport and Augmented Radiation Sensitivity Cause by Loss of RLIP76”, (c0-PI) June 2007 - May 2008
Cancer Research Foundation of North Texas, “RLIP76 (RALBP1), a multi-drug transporter: Doxorubicin transport by RLIP76 and ABCG2 in lung and breast cancer”, (co-PI) June 2007 - May 2008
Cancer Research Foundation of North Texas “Role of SMC1 as a novel transporter of xenobiotics” (co-PI) 06/01/2007-05/31/2008

Memberships
American Chemical Society
American Medical Association
American Society of Clinical Oncology
American Association for Cancer Research
Association of Scientists of Indian Origin in America
American Association for the Advancement of Science
New York Academy of Sciences
Texas Medical Association

Awards and Honors
Phi Eta Sigma Honor Society, 1979
B. A. Biochemistry, Cum Laude, 1979
Board Certification, American Board of Internal Medicine, 1990
Oncology Training Fellowship Award, American Cancer Society, 1990-1991.
Board Certification, Medical Oncology, 1991.
DHHS NIH-R29 Mechanisms of Drug Transport in Lung Cancer Cells, 1994
Young Scientist Award from the American Scientists of Indian Origin in America, 1996
DHHS NIH-R01 Mechanisms of Drug Transport in Lung Cancer Cells, 1998-2011
DHHS NIH-R01 Role of RALBP1 in Xenobiotic and Radiation Resistance, 2004-2009
Partner, Texas Oncology, 2001
Partner, U.S. Oncology, 2004
Member, Experimental Therapeutics-2 Study Section, NCI, 2003-2004
Member, Drug Discovery and Molecular Pharmacology Study Section, NCI, 2004-2006
Chairman, Cancer Program, HCA-Medical Center of Arlington, 2004-present