State-of-the-Science Workshop Report: Issues and Approaches in Low Dose–response Extrapolation for Environmental Health Risk Assessment
Contact
- Ila L. Cote
- by phone at: 919-541-4173
- by email at: cote.ila@epa.gov
- by email at: cote.ila@epa.gov
Topics included:
- the need for formalized approaches and criteria to assess the evidence for mode of action;
- the use of human vs. animal data;
- the use of mode of action information in biologically-based models; and
- the implications of interindividual variability, background disease processes and background exposures in threshold vs. nonthreshold model choice.
Background
Workshop goals were to: (1) review the state of the science for high-to-low dose-response extrapolation methods in environmental health risk assessments, (2) identify realistic approaches for the practical application of low-dose extrapolation incorporating the relevant scientific evidence to the fullest extent feasible and (3) identify areas for future work.
Next Steps
This is the final report.
Downloads/Related Links
- State-of-the-Science Workshop Report: Issues and Approaches in Low Dose–response Extrapolation for Environmental Health Risk Assessment (PDF) (31 pp, 112 KB, about PDF)
Related Link(s)
Citation
White, R. H., I. L. COTE, L. Zeise, M. Fox, F. Dominici, T. A. Burke, P. WHITE, D. HATTIS, AND J. M. Sarnet. State-of-the-Science Workshop Report: Issues and Approaches in Low Dose–response Extrapolation for Environmental Health Risk Assessment. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, (2008).