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Chemical Sampling Information |
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| 1-Butoxy-2-propanol |
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General Description
Synonyms: IAQ; Propasol Solvent B; Propylene Glycol n-Butyl Ether
OSHA IMIS Code Number: B145
Chemical Abstracts Service (CAS) Registry Number: 5131-66-8
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: UA7700000
Chemical Description and Physical Properties: Clear colorless liquid, with characteristic odor.
molecular formula: C7H16O2
molecular weight: 132.23
boiling point: 170.2°C
vapor pressure: 0.187 kPa @ 25°C
melting point: -80°C
Health Factors
Potential symptoms: Eye, skin irritation; in animals, high systemic doses caused CNS depression (lethargy, coma), gasping respiration; dacryorrhea (excessive tears), anemia, enlarged livers (with no histologic lesions; reversible) and kidney damage.
Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11).
Affected organs: Kidneys, respiratory system, eyes, skin, CNS
Notes: 1) OSHA does not have a PEL for 1-butoxy-2-propanol. 2) It is a metabolite of dipropylene glycol n-butyl ether and further metabolized by O-dealkylation to propylene glycol and butanol (metabolized to carbon dioxide) or by conjugation with sulfate or glucuronide for urinary excretion. 3) Repeated-dose inhalational studies in rats indicated a NOAEL of 700 ppm (the maximum attainable concentration in air).
Date Last Revised: 05/12/2005
Literature Basis:
- NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: UA7700000: 2-Propanol, 1-butoxy-.
- Verschuuren, H.G.: Toxicological studies with propylene glycol n-butyl ether. Occupational Hygiene 2(1-6): 311-318, 1996.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Tenax Tube
maximum volume: 30 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
article: McJilton, C.E.; S.J. Reynolds; A.J. Streifel; R.L.; Pearson. AIHAJ 51(10), p 545-549, 1990.
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