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Chemical Sampling Information: |
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| Adiponitrile |
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General Description
OSHA IMIS Code Number: A509
Chemical Abstracts Service (CAS) Registry Number: 111-69-3
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: AV2625000
Department of Transportation Regulation Number (49 CFR 172.101): 2205 153
NIOSH Pocket Guide to Chemical Hazards, Adiponitrile: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 9 mg/m3 TWA; Skin
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 18 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): Not determined
Potential symptoms: Irritation eyes, skin, respiratory system; headache, dizziness, lassitude, mental confusion, seizures; blurred vision, dilated pupils; rapid breathing and heart rate; low blood pressure; cyanosis of the skin and mucosa; INGES ACUTE = abdominal pain, nausea, vomiting
Health Effects: CNS Disturbances (HE7); Irritation-Eyes, Skin; Asphyxiant (HE17); LC50 (4-hr inhalation, rat) 386 ppm; LD50 (oral, rabbit) 22 mg/kg
Affected organs: CNS, respiratory system, cardiovascular system; eyes; skin
Note: Metabolized in the body to cyanide.
Date Last Revised: 02/25/2003
Literature Basis:
- (symptoms)
Ramaiah, S.K. and Mehendale, H.M.: Adiponitrile, in Enclyclopedia of Toxicology, Vol. 1, Wexler, P., ed. San Diego: Academic Press, 1998, pp. 28-30.
- (health effects and target organs)
NIOSH Guide to Chemical Hazards, Adiponitrile
- (rat inhalational toxicology)
Smith, L.W. and Kennedy, G.L., Jr.: Inhalation toxicity of adiponitrile in rats. Toxicol. Appl. Pharmacol. 65: 257-263, 1982.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections)
analytical solvent: Chloroform
maximum volume: 10 Liters maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
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