Chemical Sampling Information
	Methamphetamine
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: N-α-dimethyl-Benzeneethanamine; (α R)-N-α-dimethyl-Benzeneethanamine; (α S)-N-α-dimethyl-Benzeneethanamine; N-α-dimethyl-Benzeneethanamine hydrochloride OSHA IMIS Code Number: M315 Chemical Abstracts Service (CAS) Registry Number: 51-57-0 (Benzeneethanamine, N-alpha-dimethyl-, hydrochloride); 537-46-2 (Benzeneethanamine, N-alpha-dimethyl-, (alpha S)-); 7632-10-2 (Benzeneethanamine, N-alpha-dimethyl-); 33817-09-3 (Benzeneethanamine, N-alpha-dimethyl-, (alpha R)-) NIOSH, Registry of Toxic Effects (RTECS) Identification Number: SH4900000 Chemical Description and Physical Properties: varies with chemical composition Health Factors Potential symptoms: Insomnia, depression, irritability, paranoia, hallucination; stroke; myocardial infarction, cardiac arrhythmia; hyperthermia in overdose. Health Effects: Nervous system disturbances (HE7); Chronic (Cumulative) Toxicity---Heart abnormalities; abuse liability (HE3). Affected organs: CNS, cardiovascular system. Notes: OSHA does not have a PEL for methamphetamine. Methamphetamine is a Schedule II controlled substance (21 CFR 1308.12), which is approved by the FDA for the treatment of attention deficit disorder with hyperactivity and exogenous obesity. The mean elimination half-life of methamphetamine was approximately 11 hours by intravenous, intranasal and inhaled (smoked) routes of administration in eight experienced users. Injuries have occurred to first responders (police officers, emergency medical staff, fire fighters) from chemicals used in illicit methamphetamine-producing laboratories, including hydrochloric acid, ammonia, phosphine, and diethyl ether. Date Last Revised: 04/13/2006 Literature Basis: Anglin, M.D., Burke, C., Perrochet, B., Stamper, E. and Dawud-Noursi, S.: History of the methamphetamine problem. J. Psychoactive Drugs 32(2): 137-141, 2000. Burgess, J.L.: Phosphine exposure from a methamphetamine laboratory investigation. J. Toxicol. Clin. Toxicol. 39(2): 165-168, 2001. Fuller, K.: A dangerous business. Occup. Health Saf. 74(9): 188-191, 2005. Harris, D.S., Boxenbaum, H., Everhart, E.T., Sequeira, G., Mendelson, J.E. and Jones, R.T.: The bioavailability of intranasal and smoked methamphetamine. Clin. Pharmacol. Ther. 74(5): 475-486, 2003. Matoba, R.: [Cardiac lesions in methamphetamine abusers.] Nippon Hoigaku Zassi 55(3): 321-330, 2001. (English abstract in PubMed, PMID: 11905041.) No author: Public health consequences among first responders to emergency events associated with illicit methamphetamine laboratories --- selected states, 1996—1999. MMWR Weekly 49(45): 1021-1024, 2000. Schepers, R.J.F., Oyler, J.M., Joseph, R.E., Jr., Cone, E.J., Moolchan, E.T. and Huestis, M.A.: Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers. Clin. Chem. 49(1): 121-132, 2003. Uemura, K., Sorimachi, Y., Yashiki, M. and Yoshida, K.: Two fatal cases involving concurrent use of methamphetamine and morphine. J. Forensic Sci. 48(5): 1179-1181, 2003. Monitoring Methods used by OSHA On-Site Sampling Techniques/Methods: note: On-site surface sampling test kits are commercially available. OSHA neither endorses these kits nor recommends their use. The effectiveness and applicability of these kits are the responsibility of the user. All Trademarks are the property of their respective owners.