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Chemical Sampling Information |
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| Ethyl Acetate |
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General Description
Synonyms: Acetic ester, acetic ether; Ethyl ester of acetic acid; Ethyl ethanoate
OSHA IMIS Code Number: 1040
Chemical Abstracts Service (CAS) Registry Number: 141-78-6
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: AH5425000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1173 129
NIOSH Pocket Guide to Chemical Hazards, Ethyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 400 ppm, 1400 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 400 ppm, 1400 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 400 ppm, 1400 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 400 ppm, 1440 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 400 ppm, 1400 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2,000 ppm [LEL]
Potential symptoms: Eye, nose, throat irritation; cough, sore throat; headache, nausea; dizziness, drowsiness, weakness; narcosis; dermatitis.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Odor (20); Narcosis (HE8); Explosive, Flammable (HE18)
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- Vapor/air mixtures may be explosive. The IDLH is 10% of the lower explosive limit (2.0 %).
- Ethyl acetate is generally recognized as safe by the FDA as a synthetic flavoring substance or adjuvant for food (21 CFR 182.60).
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of ethyl acetate is 0.9 mg/kg/day.
- Ethyl acetate is hydrolyzed to ethanol and acetic acid. Much higher levels of ethanol than of ethyl acetate were found in tissues of a worker who died of anoxia from a toxic exposure to ethyl acetate.
Date Last Revised: 02/01/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Ethyl Acetate.
- International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl acetate.
- U.S. EPA Integrated Risk Information System: Ethyl acetate (CASRN 141-78-6).
- Coopman, V.A., Cordonnier, J.A., and De Meyere C.A.: Fatal workplace accident involving ethyl acetate: a distribution study. Forensic Sci. Int. 154(2-3): 92-95, 2005.
- Pohanish, R.P. (editor): Ethyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1039-1041.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon disulfide
alternate solvent: (99:1) Carbon Disulfide:Dimethylformamide
alternate solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 6 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1457)
method classification: Fully Validated
note: Samples must be refrigerated for shipment to laboratory.
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