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Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Cote d'Ivoire.
AIDS Research and Human Retroviruses 2002;18:171-177.
Jennes W, Sawadogo S, Koblavi-Deme S, Vuylsteke B, Maurice C, Roels
TH, Chorba T, Nkengasong JN, Kestens L.
Abstract
The role of beta-chemokines in controlling HIV replication in vivo is still
controversial. Therefore, the association between HIV-1 plasma viral load
and the capacity of CD4(+) and CD8(+) T cells to produce beta-chemokines
was studied in 28 antiretroviral drug-naive HIV-1-infected female sex workers
in Abidjan, Cote d'Ivoire. Percentages of beta-chemokine-positive T cells
were measured in peripheral blood mononuclear cells by flow cytometry after
intracellular staining for RANTES (regulated on activation, normal T expressed
and secreted), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta.
HIV-1-infected subjects had higher percentages of MIP-1alpha- and MIP-1beta-positive
CD4(+) and CD8(+) T cells (p < 0.02) and of RANTES-positive CD8(+) T cells
(p = 0.054) than uninfected controls. Percentages of RANTES- and MIP-1beta-positive
CD8(+) T cells correlated directly with HIV-1 plasma viral load (p < 0.02).
Percentages of beta-chemokine-positive CD4(+) and CD8(+) T cells correlated
directly with percentages of HLA-DR-positive T cells (p < 0.02) and inversely
(except RANTES in CD4(+) T cells) with absolute numbers of CD4(+) T cells
(p < 0.05) in peripheral blood. These data indicate that increased percentages
of beta-chemokine-producing T cells in HIV-1-infected subjects correlate
with disease progression and are a sign of viremia-driven chronic T cell
activation.