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daptomycin A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum anitbiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) | Cubicin | | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) | LY146032 | | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) | N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone | | ![](https://webarchive.library.unt.edu/web/20081024114728im_/http://www.cancer.gov/images/spacer.gif) |
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