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The Human Genome Project was completed in 2003. One of the key research
areas was Chromosome Mapping. This page details that research.
Mapping is the construction of a series of chromosome
descriptions that depict the position and spacing of unique, identifiable
biochemical landmarks, including some genes, that occur on the DNA of
chromosomes.
In 1990, DOE initiated projects to enrich the developing chromosome
maps with markers for genes. In 1993 this effort led to the establishment
of the Integrated Molecular Analysis of Gene Expression (I.M.A.G.E.) Consortium.
I.M.A.G.E. members develop and array cDNA clones (representing the gene
coding regions of the genome) and make them available worldwide.
Area |
HGP Goal |
Standard Achieved |
Date Achieved |
Genetic Map |
2- to 5-cM
resolution map
(600 – 1,500 markers) |
1-cM
resolution map
(3,000 markers)
|
September 1994 |
Physical Map |
30,000 STSs |
52,000 STSs |
October 1998 |
Gene Identification |
Full-length human cDNAs |
15,000
full-length
human cDNAs |
March 2003 |
For a more detailed explanation of mapping, see the U.S. DOE Primer
on Molecular Genetics.
Gene Maps
Related Articles from Human Genome
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