This booklet was prepared at the request of the U.S. Department of Energy, Office of Health and Environmental Research, as an overview of the Human Genome Project, especially the role of the DOE in this international, multiagency effort. Though edited and produced at the Lawrence Berkeley National Laboratory, this account aims to reflect the full scope of the DOE-sponsored effort. In pursuit of this goal, the contributions of many have been essential. Within the Department of Energy, David A. Smith deserves special mention. He managed the DOE Human Genome Program until his retirement this year, and he was the principal catalyst of this effort to summarize its achievements. Also contributing program descriptions, illustrations, advice, and criticism: at DOE, Daniel W. Drell; at Berkeley, Michael Palazzolo, Christopher H. Martin, Sylvia Spengler, David Gilbert, Joseph M. Jaklevic, Eddy Rubin, Kerrie Whitelaw, and Manfred Zorn; at Lawrence Livermore National Laboratory, Anthony Carrano, Gregory G. Lennon, and Linda Ashworth; at Los Alamos National Laboratory, Robert K. Moyzis and Larry Deaven; at Oak Ridge National Laboratory, Lisa Stubbs; at the National Center for Genome Resources, Christopher Fields; and at Affymetrix, Robert J. Lipshutz. Behind the scenes, many others no doubt had a hand.

Douglas Vaughan, Editor

Design: Debra Lamfers Design
Illustrations: Marilee Bailey
Web site design: Mike Wooldridge

This document was prepared as an account of work sponsored by the United States Government. While this document is believed to contain correct information, neither the United States Government nor any agency thereof, nor The Regents of the University of California, nor any of their employees, makes any warranty, express or implied, or assumes any legal responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by its trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof, or The Regents of the University of California. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof, or The Regents of the University of California.

Ernest Orlando Lawrence Berkeley National Laboratory is an equal opportunity employer.

Prepared for the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. PUB-773/July 1996.

To Know Ourselves was prepared at the request of the U.S. Department of Energy, Office of Health and Environmental Research, as an overview of the Human Genome Project.