Scientific Peer Review of ESL Methodology
In 2004 and 2005, the TCEQ documented its methodology for
developing ESLs and contracted with Toxicology Excellence for Risk
Assessment (TERA) 
to conduct an independent,
scientific peer review of the methodology. TERA is a nonprofit
organization in Cincinnati, Ohio, that is internationally
recognized for its peer reviews. The purpose of the peer review is
to ensure that the TCEQ methodology for deriving ESLs meets the
highest scientific standards.
A panel of noted scientific experts in inhalation toxicology,
acute and chronic hazard identification and dose response, and
cancer and non-cancer risk assessment conducted a meeting on June
27 and 28, 2005, and discussed various issues and concerns with the
ESL methodology.
List of Panel Members (PDF) (Help
with PDF)
Charge to Reviewers (PDF)
ESL Methodology Draft Document (PDF)
List of Key References (PDF)
Peer Review Report
In October 2005, TERA published a peer review report that
summarized the comments and suggested improvements made by the
panel and the public at the June 2005 peer review meeting.
Final Meeting Report (PDF)
Final Meeting Report Appendixes (PDF)
TCEQ Responses to Peer Review Report
The Toxicology Section's responses to the peer reviewer's and the
public's comments are now available.
TCEQ Responses to Peer Review Report (PDF)
Guidelines to Develop ESLs, ReVs, and URFs
(Public Comment Draft)
The ESL Methodology has been revised by the Toxicology Section to
address the issues raised by the scientific peer review panel. The
document is now referred to as Guidelines to Develop Effects
Screening Levels, Reference Values, and Unit Risk Factors.
Guidelines to Develop ESLs, ReVs, and URFs,
with Appendices A-E (PDF)
APPENDIX F of Guidelines to Develop ESLs, ReVs, and URFs (PDF)
APPENDIX G of Guidelines to Develop ESLs, ReVs, and URFs (PDF)
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