Duane
B. Huggett
Assistant
Professor
Department
of Biology
Institute
of Applied Sciences
(T)
940-891-6956
(F)
940-565-4297
Education
Ph.D.
Pharmacology and Toxicology, 2001,
M.S.
Biological Sciences, 1998,
B.S.
Biological Sciences, 1996, Virginia Polytechnic and
Research
Interests
My research interests are in four broad areas: 1) Pharmacology and
Toxicology; 2) Bioconcentration and bioaccumulation of contaminants; 3) Computational
toxicology and, 4) Comparative pharmacology and physiology.
Experience
·
2006-Present, Assistant Professor,
·
2003-2006, Principal Scientist, Pfizer Global Research and
Development
·
2001-2003, Research Scientist, Pfizer Global Research and
Development
Current and Past Funding
·
Alternative methodologies for bioconcentration
testing in fish. (2010-2012). European
Chemical Industry Council (CEIC) and International Life Sciences
Institute. (Principal Investigator)
·
Cardiovascular parameters in fish influencing bioconcentration and
bioaccumulation. (2007-2010). International Life Sciences Institute-Human and
Environmental Sciences Institute (ILSI-HESI) (Principal Investigator)
·
Bioconcentration and
Early Life Stage Toxicity of Selected Pharmaceuticals in Fish (2007-2010). Pfizer
Global Research and Development (Principal Investigator)
·
Interaction of Nicotine and Menthol in Mice (2008-2009). (Principal
Investigator)
·
In vitro and In vivo metabolism of clofibric acid. (2007-2008)
Pfizer Global Research and Development (Principal Investigator)
·
In Vivo metabolism of propranolol (2007-2008)
Pfizer Global Research and Development and AstraZeneca Brixham
(Principal Investigator)
Laboratory Group
David Hala (Post-Doc)
Lene Peterson (Post-Doc)
Kati Stoddard (PhD)
Santos Garcia (PhD)
Wendy Pace (PhD)
Michael Foster (PHD)
Matt Overturf (Ph.D.)
Carmen Overturf (Ph.D.)
Jamie Stine (Undergraduate-McNair Scholar)
Dusten Snodgrass (Undergraduate-McNair Scholar)
Past Students
Cristi Gomez
(Ph.D. in 2010)
Crystal Colbert (M.S. in 2010)
Selected Publications
P.Paulos, T. Runnels, J.P. Sumpter, G. Nallani, D.B. Huggett. (20010). Reproductive
Responses in Fathead Minnow and Japanese Medaka
Following Exposure to a synthetic progestin, Norethindrone. Aquatic Toxicology.
(In Press).
D.
Hala, A. Amin, A. Mikler, D.B. Huggett. (20010). A Constraint based Stoichiometric Model of the Steroidogenic
Network of Zebrafish.
Journal of
Biological Systems. (In Press).
S.F. Owen, D.B.
Huggett, T.H. Hutchinson, M.J. Hetheridge, L.B. Kinter,
J.F. Ericson, J.P. Sumpter. (2008). Cardiovascular
pharmaceutical uptake from water into trout plasma in vivo: changes in biometry and growth. Aquatic Toxicology 93:217-224.
G.T. Ankley, B.W. Brooks, D.B. Huggett, J.P.
Sumpter. (2007). Repeating History:
Pharmaceuticals in the Environment. Environmental
Science and Technology 41:8211-8217.
S.W.Kennedy,
S.Euling, D.B.Huggett, W.De Coen, J.Snape,
T.Zacharewski, J.Kanno. (2007). The
Development of Genomic-Based Screening Assays for Ecotoxicology. In. G.Ankley (ed) SETAC Pellston
Workshop: The Role of Ecotoxicogenomics in Ecological
Risk Assessment.
J.L. Flippin, D.B. Huggett, C.M. Foran. (2007). Changes in the timing of reproduction
following chronic exposure to ibuprofen in Japanese medaka. Aquatic
Toxicology 83:73-78.
D.B. Huggett, W.H. Benson, K. Chipman, J.C. Cook, L.E. Gray,
L.B. Kinter, R.D. Meyerhoff, V. Trudeau. (2005). The Role of Mammalian Data in
Determining Pharmaceutical Responses in Aquatic Organisms. In R.T. Williams (ed) SETAC
Pellston Workshop: Pharmaceuticals in the Environment.
T.H. Hutchinson,
S. Barrett, M. Busby, D. Constable, A. Hartman, E. Hayes, D. Huggett, R. Lange,
A.D. Lillicrap, J.O. Straub, R.S. Thompson.
(2003) Proposed Reduction in Fish Acute Ecotoxicity
Testing for Environmental Assessments of Pharmaceuticals. Environmental Toxicology
and Chemistry 22:3031-3016.
D.B. Huggett, J.C.
Cook, J.E. Ericson, R.T. Williams.
(2003) Theoretical Model For Prioritizing Potential Impacts of Human Pharmaceuticals
To Fish. Journal of
Human and Ecological Risk Assessment. 9:1789-1799.
D.B. Huggett, C.M. Foran,
D.B. Huggett,
D.B.
Huggett,
D.B. Huggett, D.Schlenk, B.R.
Griffin. (2001) Toxicity of Copper in an Oxic Stream Sediment Receiving
Aquaculture Effluent. Chemosphere
44: 361-367
D.B.
Huggett, W.B. Gillespie, Jr.,and J.H. Rodgers, Jr. (1999) Copper Bioavailability in