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Lipid Droplets
Isolated lipid droplets from Arabidopsis thaliana seeds stained with a fluorescent dye (BODIPY 493/503). Scale bar is 10 microns.
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UNT researchers make advancements in cellular biology
DENTON (UNT), Texas -- A process developed by a UNT doctoral student and his mentors is giving cellular biologists a new window into both plant and animal physiology. Previously, researchers could determine the chemical composition of a sample, but could not determine where the chemicals came from within the sample. Now biologists and chemists will be able to create chemical maps of cellular structures at the molecular level. This advancement will result in a better understanding of how plants and animals function. Patrick Horn, a UNT doctoral student under the direction of UNT biologist Dr. Kent Chapman, pioneered the process with help from students in Dr. Guido Verbeck's Imaging Mass Spectrometry Laboratory. Horn used technology developed by Verbeck, an assistant professor in the UNT Department of Chemistry, to visualize the chemical composition of lipid droplets. Lipids are present in all organisms, and typically are stored as fats and oils in small droplets. "Understanding how lipid droplets form and function has major significance," said Horn. "Lipid storage and mobilization underlies human health issues, such as obesity and diabetes. The ability to study these structures on the nanoscale may result in ways to modify how fats are stored and burned." The team's research recently was published in the Journal of Biological Chemistry, and also was recognized by the Faculty of 1000, an organization that identifies and evaluates the most important articles in biology and medical research publications. Horn began his research on lipids in the fall of 2008, and he says that he'll continue working with Chapman and Verbeck until his scheduled graduation in 2013. He says that he plans to become a professor once he completes his doctorate. "I am excited that my project has provided so many outlets for more questions. Every month we are receiving emails from scientists around the globe wanting to apply this process to their research," said Horn.
UNT News Service Phone Number: (940) 565-2108
Contact: Alyssa Yancey (940) 565-3510
Email: alyssa.yancey@unt.edu
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