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PeerJ PrePrints - where biology is heading

Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3 -/- mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade...

["Biochemistry","Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.498v1

To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.464v3

In the last years the number of long distance runners who wear minimal footwear or run completely barefoot increased considerably. There is an ongoing debate about the benefits and risks of running in minimal footwear/barefoot instead of running in conventional...

["Bioinformatics","Biophysics","Orthopedics"]
doi:10.7287/peerj.preprints.497v1

The measurement of running style must be ecologically valid. The individual running style has an impact on the running performance as well as the running injury risk. In order to increase the performance and lower the injury risk, runners should be educated towards...

["Bioinformatics","Biophysics","Public Health"]
doi:10.7287/peerj.preprints.496v1

Common barefoot running shoes or minimal footwear have one or several of the following properties/deficiencies, depending on the type and brand and personal taste: - Coverage of a considerable fraction of the foot’s surface with textile/plastic leading to sub-optimal...

["Public Health"]
doi:10.7287/peerj.preprints.495v1

The applicability, transfer, and scalability of visible/near-infrared (VNIR)-derived soil models are still poorly understood. The objectives of this study in Florida, U.S. were to: (i) compare three methods to predict soil total carbon (TC) using five fields (local...

["Agricultural Science","Biogeography","Ecology","Environmental Sciences","Soil Science"]
doi:10.7287/peerj.preprints.494v1

A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level dependent) fMRI for detecting the effects of the adenosine A2a antagonist tozadenant in Parkinson disease . Only ASL detected the direct...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.493v1

Global change will causes species range shifts, affecting species interactions. The conservation implications of species range shifts are widely unknown. Through forming an ecology-bioinformatics partnership at the National Evolutionary Synthesis Center-Encyclopedia...

["Animal Behavior","Biodiversity","Bioinformatics","Conservation Biology"]
doi:10.7287/peerj.preprints.492v1

Certain biological traits seem to predispose some species to greater extinction risk than others and, when vulnerability information is limited, could be used as proxies to identify understudied species likely in need of protection. In the past, identifying broadly...

["Conservation Biology","Ecology","Plant Science"]
doi:10.7287/peerj.preprints.491v1

Background: Mexico is the fourth richest country in amphibians and the second country with the highest quantity of threatened amphibian species, and this number could be higher as many species are too poorly known to be accurately assigned to a risk category. The...

["Biodiversity","Bioinformatics","Computational Biology","Conservation Biology"]
doi:10.7287/peerj.preprints.490v1

Triclosan (TCS) is a widely used antibacterial agent that has become a ubiquitous contaminant in freshwater, estuary and marine environments. Concerns for potential adverse effects of TCS have been described in several recent risk assessments. Effects on freshwater...

["Environmental Sciences","Microbiology","Toxicology"]
doi:10.7287/peerj.preprints.489v1

Local adaptation is an important process shaping within species diversity. In recent years, population genetic analyses, which complement organismal approaches in advancing our understanding of local adaptation have become widespread. Here we focus on using population...

["Ecology","Evolutionary Studies","Genetics"]
doi:10.7287/peerj.preprints.488v1

Obstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e. infection inflammation, thrombosis, endocrine...

["Gynecology and Obstetrics","Hematology"]
doi:10.7287/peerj.preprints.487v1

Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications named the great obstetrical syndromes (preeclampsia, intrauterine...

["Gynecology and Obstetrics","Immunology"]
doi:10.7287/peerj.preprints.486v1

Objectives: To investigate to what degree radiofrequency electromagnetic radiation, induced by a mobile phone placed on the chest, impacts cardiac rhythm. Design: n=1, single blinded pilot study Setting: Academic hospital, Maastricht, the Netherlands Participants:...

["Public Health","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.485v1

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A PeerJ 'PrePrint' is a draft that has not yet been peer reviewed for formal publication. Similar to preprint servers that already exist (for example arXiv.org), authors can submit draft, incomplete, or final versions of articles they are working on.

By using this service, authors establish precedent; they can solicit feedback, and they can work on revisions of their manuscript. Once they are ready, they can submit their PrePrint manuscript into the peer reviewed PeerJ journal (although it is not a requirement to do so).

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