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  1. Neuroscience
Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice
Sensory-driven calcium spikes in Purkinje cells are not binary; instead, they are graded and can provide information about the strength of a periocular airpuff stimulus known to drive learning.
Farzaneh Najafi, Andrea Giovannucci, Samuel S-H Wang, Javier F Medina
Research article
  1. Cell biology
  2. Genes and chromosomes
Histone supply regulates S phase timing and cell cycle progression
Controlling cell cycle progression in a developing embryo directly depends on de novo histone supply and a specialized surveillance mechanism for nucleosome assembly.
Ufuk Günesdogan, Herbert Jäckle, Alf Herzig
Research article
  1. Biophysics and structural biology
Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex
X-ray crystallography reveals the structural framework for understanding the function of mammalian transcriptional repression in the cellular circadian clock.
Shannon N Nangle, Clark Rosensweig, Nobuya Koike, Hajime Tei, Joseph S Takahashi, Carla B Green, Ning Zheng
Research article
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  1. Biochemistry
  2. Cell biology
MicroRNA-mediated repression of nonsense mRNAs
microRNAs can serve as a surveillance system to repress nonsense mRNAs by recognizing miRNA-responsive elements in the open reading frame region downstream of the premature termination codon.
Ya Zhao, Jimin Lin, Beiying Xu, Sida Hu, Xue Zhang, Ligang Wu
Research article
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  1. Biochemistry
  2. Biophysics and structural biology
DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
The Mcm2-7 motor unwinds DNA using an approach distinct from that of superfamily III helicases, and accesses multiple ring configurations and assembly states during the initiation of DNA replication.
Alessandro Costa, Ludovic Renault, Paolo Swuec, Tatjana Petojevic, James J Pesavento, Ivar Ilves, Kirsty MacLellan-Gibson, Roland A Fleck, Michael R Botchan, James M Berger
Research article
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  1. Genomics and evolutionary biology
  2. Human biology and medicine
Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks
The theory of Buffered Qualitative Stability uses the importance of biological robustness to explain many features of gene regulatory networks in a wide range of organisms, and has implications for diverse biological phenomena including the ability of bacteria and cancer cells to ‘loosen’ their robustness and hence evade treatment.
Luca Albergante, J Julian Blow, Timothy J Newman
Research article
  1. Microbiology and infectious disease
Prion propagation can occur in a prokaryote and requires the ClpB chaperone
The bacterium Escherichia coli possesses a permissive cytoplasmic environment and the requisite molecular machinery to support the propagation of prions.
Andy H Yuan, Sean J Garrity, Entela Nako, Ann Hochschild
Research article
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  1. Biophysics and structural biology
  2. Microbiology and infectious disease
Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP
Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.
Debashree Chatterjee, Richard B Cooley, Chelsea D Boyd, Ryan A Mehl, George A O'Toole, Holger Sondermann
Research article
  1. Cell biology
  2. Developmental biology and stem cells
Microtubules provide directional information for core PCP function
The Fat/Dachsous/Four-jointed (Ft/Ds/Fj) system provides a spatial signal to organize core PCP proteins via the polarization of microtubules.
Maja Matis, David A Russler-Germain, Qie Hu, Claire J Tomlin, Jeffrey D Axelrod
Research article
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  1. Human biology and medicine
  2. Neuroscience
Nuclear envelope protein MAN1 regulates clock through BMAL1
A protein within the nuclear membrane, MAN1, controls the expression of the circadian clock gene, BMAL1, in an example of cross-talk between two major gene regulatory pathways.
Shu-Ting Lin, Luoying Zhang, Xiaoyan Lin, Linda Chen Zhang, Valentina Elizabeth Garcia, Chen-Wei Tsai, Louis Ptáček, Ying-Hui Fu
Research article
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