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Radiotracer Chemistry
Radiotracers are at the heart of molecular imaging. At Brookhaven we build
on a history of cyclotron targetry chemistry and on innovation in rapid
organic synthesis to develop new methods for the incorporation of C-11,
F-18 and N-13 into small precursors and complex molecules including nanomaterials.
These are designed to image specific biochemical transformations and the movement
of environmental toxicants in vivo.
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Imaging Instrumentation
Advances in imaging instrumentation have increased the pace of discovery
in a broad cross-section of the sciences ranging from nuclear physics to
astrophysics to biology and neuroscience. At Brookhaven, we develop quantitative
radiation detection technologies with improved spatial resolution and sensitivity;
high field MRI technology and; optical imaging instruments and their combination for
simultaneous imaging.
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Plant Science
Over the past 5 years we have developed a plant metabolism laboratory building a ‘radiotracer
toolkit’ of C-11, N-13 and F-18 labeled tracers and tracer methodologies to probe specific
metabolic pathways in plants and to examine how these are affected by genes and by environmental
stressors. An overarching goal is to be able to identify manipulations that influence carbon
sequestration and improve energy crop growth.
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Neuroimaging Research (NIAAA
Intramural & NIH)
Innovations in radiotracer chemistry and nuclear imaging instrumentation and
their combination with other neuroscience methods, form the backbone for
preclinical and clinical neuroscience research at Brookhaven. Research is
advanced by developing radiotracers to image different cellular elements
(enzymes, receptors, transporters, drug binding sites) and using these as
tools to understand how genes, drugs, disease (addiction, obesity) and
aging affect the brain (funded by NIAAA Intramural Program at Brookhaven;
NIH grants; industry funding)
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One of ten national laboratories overseen and primarily
funded by the Office of Science of the U.S. Department of Energy (DOE), Brookhaven
National Laboratory conducts research in the physical, biomedical, and environmental
sciences, as well as in energy technologies and national security. Brookhaven Lab also
builds and operates major scientific facilities available to university, industry and
government researchers. Brookhaven is operated and managed for DOE's Office of Science by
Brookhaven Science Associates, a limited-liability company founded by Stony Brook University,
the largest academic user of Laboratory facilities, and Battelle, a nonprofit, applied science
and technology organization.