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Sponsored by: |
University of Rochester |
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Information provided by: | University of Rochester |
ClinicalTrials.gov Identifier: | NCT00861341 |
The purpose of this study is to determine how pioglitazone and aspirin affect platelets in the blood of diabetic and non-diabetic subjects. Platelets are small cells in the blood that help with blood clotting. Pioglitazone is a drug that is used to lower blood sugar and fats by helping the body to use insulin correctly. Pioglitazone is presently used to treat diabetes but has not been approved for non-diabetics. This study will determine whether pioglitazone reduces the activity of platelets in people who are or are not also taking aspirin.
Condition | Intervention | Phase |
---|---|---|
Diabetes Platelet Aggregation Healthy |
Drug: pioglitazone and aspirin |
Phase II |
Study Type: | Interventional |
Study Design: | Diagnostic, Non-Randomized, Open Label, Single Group Assignment |
Official Title: | Effects of Pioglitazone on Platelet Function |
Estimated Enrollment: | 40 |
Study Start Date: | December 2008 |
Estimated Primary Completion Date: | July 2010 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 21 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Charles Francis, MD | 585-275-3761 | Charles_Francis@urmc.rochester.edu |
United States, New York | |
University of Rochester | Recruiting |
Rochester, New York, United States, 14642 | |
Contact: Charles Francis, MD 585-275-3761 Charles_Francis@urmc.rochester.edu |
Responsible Party: | University of Rochester ( Charles Francis, MD ) |
Study ID Numbers: | 24695 |
Study First Received: | March 9, 2009 |
Last Updated: | March 12, 2009 |
ClinicalTrials.gov Identifier: | NCT00861341 History of Changes |
Health Authority: | United States: Institutional Review Board |
Pioglitazone Thiazolidenediones Platelet Function Effects of pioglitazone on platelet aggregation in normal and diabetic patients before and after the administration of aspirin. |
Anti-Inflammatory Agents Pioglitazone Cyclooxygenase Inhibitors Diabetes Mellitus Fibrinolytic Agents Healthy Cardiovascular Agents Fibrin Modulating Agents |
Hypoglycemic Agents Aspirin Analgesics, Non-Narcotic Platelet Aggregation Inhibitors Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Pioglitazone Cyclooxygenase Inhibitors Hematologic Agents Physiological Effects of Drugs Enzyme Inhibitors Fibrinolytic Agents Cardiovascular Agents Pharmacologic Actions Fibrin Modulating Agents |
Hypoglycemic Agents Aspirin Analgesics, Non-Narcotic Sensory System Agents Therapeutic Uses Platelet Aggregation Inhibitors Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |