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CDC HomeHIV/AIDS > Topics > Research > Prevention Research Synthesis > 2009 Compendium of Evidence-Based HIV Prevention Interventions

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Promising-Evidence Interventions
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Promising-Evidence HIV behavioral interventions include interventions that have been sufficiently evaluated and have shown significant effects in eliminating or reducing sex- or drug-related risk behaviors, reducing the rate of new HIV/STD infections, or increasing HIV-protective behaviors. These interventions meet the PRS efficacy criteria for promising evidence and are considered to be scientifically sound and to provide sufficient scientific evidence of efficacy.

The PRS efficacy review process has identified
23 promising-evidence individual- and group-level interventions and
5 promising-evidence community-level interventions
(through June 2009)

KEY: HS=Heterosexual; HIV+=HIV-positive; HR=High-risk; MSM=Men who have sex with men; DU=Drug users; M=Male; F=Female; T=Transgender; W=White; AA=African American; AI=American Indian; H=Hispanic; API=Asian/Pacific Islander; O=Other racial/ethnic group; GLI=group-level intervention; ILI=individual-level intervention; CLI = community-level intervention

  • ARK
    Risk category: HR Youth
    Sex: 68% M, 32% F
    Race: 75% W, 22% AA, 2% AI, 1% H
    Intervention level: GLI
  • BRAINE
    Risk category: DU
    Sex: 62% M, 38% F
    Race: 90% W, 10% O
    Intervention level: ILI
  • Cognitive Behavioral STD/HIV Risk-Reduction
    Risk category: HS Adult
    Sex: 63% M, 37% F
    Race: 46% AA, 29% W, 17% H, 8% O
    Intervention level: ILI
  • Community PROMISE NEW 2008
    Risk category: DU, HR Youth, HS Adult, MSM
    Sex: 45% M, 55% F
    Race: 54% AA, 22% W, 19% H, 5% O
    Intervention level: CLI
  • Condom Promotion
    Risk category: HS Adult
    Sex: 100% F
    Race: 79% W, 8% H, 5% API, 4% AI, 3% AA, 1% O
    Intervention level: GLI
  • Doing Something Different
    Risk category: HS Adult
    Sex: 71% M, 29% F
    Race: 92% AA, 8% O
    Intervention level: GLI
  • DUIT NEW 2008
    Risk category: DU
    Sex: 66% M, 33% F, 1% T
    Race: 63% W, 17% H, 11% O, 8% AA
    Intervention level: GLI
  • Focus on Youth
    Risk category: HR Youth
    Sex: 56% M, 44% F
    Race: 100% AA
    Intervention level: GLI
  • HIV Education and Testing
    Risk category: HS Adult
    Sex: 67% M, 33% F
    Race: 88% AA, 12% O
    Intervention level: ILI
  • Insights
    Risk category: HS Adult
    Sex: 100% F
    Race: 69% W, 19% AA, 12% O
    Intervention level: ILI
  • Intensive AIDS Education
    Risk category: HR Youth, DU
    Sex: 100% M
    Race: 66% AA, 33% H, 2% W
    Intervention level: GLI
  • Mpowerment NEW 2008
    Risk category: MSM
    Sex: 100% M
    Race: 81% W, 7% API, 6% H, 4% AA, 2% O
    Intervention level: CLI
  • Nia
    Risk category: HS Adult
    Sex: 100% M
    Race: 100% AA
    Intervention level: GLI
  • Options/Opciones Project NEW 2008
    Risk category: HIV+
    Sex
    : 58% M, 42% F
    Race: 38% AA, 35% H, 22% W, 5% O
    Intervention level: ILI
  • Partnership for Health (Loss-Frame)
    Risk category: HIV+
    Sex: 86% M, 14% F
    Race: 41% W, 37% H, 16% AA, 6% O
    Intervention level: ILI
  • POL NEW 2008
    Risk category: MSM
    Sex: 100% M
    Race: 86% W, 14% AA or H
    Intervention level: CLI
  • RAPP NEW 2008
    Risk category: HS Adult
    Sex: 100% F
    Race: 73% AA, 27% O
    Intervention level: CLI
  • REAL Men NEW 2008
    Risk category: HR Youth
    Sex: 100% M
    Race: 96% AA
    Intervention level: GLI
  • Real Men Are Safe (REMAS) NEW 2009
    Risk category: DU
    Sex: 100% M
    Race: 56% W, 28% AA, 13% H, 2% AI, 1% API, <1% O
    Intervention level: GLI
  • RESPECT
    Brief Counseling (Best Evidence)
    Enhanced Counseling
    (Promising Evidence)

    Risk category: HS Adult
    Sex: 57% M, 43% F
    Race: 59% AA, 19% H, 16% W, 6% O
    Intervention level: ILI
  • Safer Sex
    Risk category: HR Youth
    Sex: 100% F
    Race: 49% AA, 18% H, 17% O, 14% W
    Intervention level: ILI
  • Safer Sex Skills Building (SSSB) NEW 2009
    Risk category: HS Adult, DU
    Sex: 100% F
    Race: 58% W, 24% AA, 9% H, 9% O
    Intervention level: GLI
  • Safety Counts
    Risk category: DU
    Sex: 67% M, 33% F
    Race: 47% AA, 28% W, 20% H, 4% AI, 1% API
    Intervention level: GLI, ILI
  • SEPA
    Risk category: HS Adult
    Sex: 100% F
    Race: 100% H
    Intervention level: GLI
  • Sniffer
    Risk category: DU
    Sex: 70% M, 30% F
    Race: 51% W, 26% AA, 23% H
    Intervention level: GLI
  • Street Smart
    Risk category: HR Youth
    Sex: 51% M, 49% F
    Race: 53% AA, 30% H, 16% O
    Intervention level: GLI
  • Teen Health Project NEW 2008
    Risk category: HR Youth
    Sex: 50% M, 50% F
    Race: 51% AA, 20% A, 20% O, 5% W, 3%H, 1% AI
    Intervention level: CLI
  • TLC
    Risk category: HIV+, HR Youth
    Sex: 72% M, 28% F
    Race: 37% H, 27% AA, 19% W, 17% O
    Intervention level: GLI
Last Modified: August 24, 2009
Last Reviewed: August 24, 2009
Content Source:
Divisions of HIV/AIDS Prevention
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
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