The first PRS efficacy review included studies published between 1988 and 1996 and resulted in the identification of 24 evidence-based interventions.  These interventions were summarized in the Compendium of HIV Prevention Interventions with Evidence of Effectiveness (CDC, 1999) [1].  This review was updated a few years later to include studies published up to the year 2000 and resulted in identifying an additional 8 evidence-based interventions (Kay et al., 2003) [17].

As the United States has entered the third decade of the HIV/AIDS epidemic, HIV behavioral intervention research has matured and become more rigorous.  To reflect the scientific progress in the field, in 2004, the PRS team strengthened its efficacy criteria for evaluating individual- and group-level (ILI/GLI) behavioral interventions (Lyles et al., 2006) [18]. PRS completed a review of the HIV prevention research literature published between 2000 and 2004 using these revised efficacy criteria for ILIs/GLIs. This review resulted in the identification of 18 best-evidence and 10 promising-evidence ILIs and GLIs (Lyles et al., 2007)[19].

The efficacy review is an ongoing process to identify evidence-based HIV behavioral interventions as quickly as possible after publication. PRS updates this website periodically to provide timely information to the HIV prevention field. The 2008 update, through May 2008, added an additional 6 best-evidence and 3 promising-evidence interventions for a total of 37 best-evidence and 21 promising-evidence ILIs and GLIs. In 2008, the PRS team developed specific efficacy criteria for best-evidence CLIs and efficacy criteria for promising-evidence CLIs and completed a review of all CLIs published between January, 1988 and May, 2008. This review resulted in the identification of 5 promising-evidence CLIs.

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