The original PRS efficacy review, including studies published between 1988 and 1996, identified 24 evidence-based behavioral interventions. These interventions were summarized in the Compendium of HIV Prevention Interventions with Evidence of Effectiveness (CDC, 1999) [1].  Refer to Review findings for more details about the original and updated findings. This original review was based on the Compendium criteria. Since then PRS strengthened its criteria for identifying evidence-based, individual- and group-level behavioral interventions. More details about these criteria can be found at Efficacy criteria.

Half of the 24 HIV behavioral interventions that were identified in the original Compendium of HIV Prevention Interventions with Evidence of Effectiveness using the less rigorous Compendium criteria meet either the current best-evidence criteria or the current promising-evidence criteria. There are 8 of the original 24 Compendium interventions that do not meet the current criteria for best- or promising-evidence, most commonly due to low retention rates or small analytical sample sizes. These ILIs and GLIs are listed below, and most fit in Tier III of the Tiers of Evidence Framework.

CDC-funded programs using DEBIs that among the 8 ILIs/GLIs not meeting the best-evidence or promising-evidence criteria can continue implementing these interventions for the time being. Agencies that are planning to implement a new ILI, GLI, or CLI are encouraged to select an intervention from among the best-evidence or promising-evidence ILI, GLI, and CLI interventions.

KEY: HS=Heterosexual; HIV+=HIV-positive; HR=High-risk; MSM=Men who have sex with men; DU=Drug users; M=Males; F=Females; W=White; AA=African American; AI=American Indian; H=Hispanic; API=Asian/Pacific Islander; O=Other racial/ethnic group; GLI=group-level intervention; ILI=individual-level intervention

Individual-level and group-level interventions meeting previous Compendium criteria: 

• Behavioral Self-Management and Assertion Skills
  Risk category: MSM
  Sex: 100% M
  Race: 87% W, 13% AA or H
  Intervention level: GLI

• Cognitive-Behavioral Skills Training Group
  Risk category: HS Adult
  Sex: 100% F
  Race: 87% AA, 6% W, 4% AI, 3% H
  Intervention level: GLI

• Condom Skills Education
  Risk category: HS Adult
  Sex: 69% M, 41% F
  Race: 76% AA, 15% H, 9% O
  Intervention level: GLI

• Enhanced AIDS Education
  Risk category: DU
  Sex: 67% M, 33% F
  Race: 81% W, 19% O
  Intervention level: ILI , GLI

• Reducing AIDS Risk Activity
  Risk category: HS Adult
  Sex: 100% F
  Race: 57% AA, 40% W, 3% O
  Intervention level: GLI

• SISTA
  Risk category: HS Adult
  Sex: 100% F
  Race: 100% AA
  Intervention level: GLI

• Skill Building
  Risk category: DU
  Sex: 100% F
  Race: 64% H, 36% AA
  Intervention level: GLI

• Small-group Lecture Plus Skill Training
  Risk category: MSM
  Sex: 100% M
  Race: 95% W, 2% AA, 1% API, 1% H, 1% O
  Intervention level: ILI , GLI

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