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NIOSH Safety and Health Topic:

Organic Solvents

Solvents are substances that are capable of dissolving or dispersing one or more other substances. Organic solvents are carbon-based solvents (i.e., they contain carbon in their molecular structure). Millions of U.S. workers are exposed to organic solvents that are used in such products as paints, varnishes, lacquers, adhesives, glues, and degreasing/cleaning agents, and in the production of dyes, polymers, plastics, textiles, printing inks, agricultural products, and pharmaceuticals.

Many organic solvents are recognized by NIOSH as carcinogens (e.g., benzene, carbon tetrachloride, trichloroethylene), reproductive hazards (e.g., 2-ethoxyethanol, 2-methoxyethanol, methyl chloride), and neurotoxins (e.g., n-hexane, tetrachloroethylene, toluene). Many different classes of chemicals can be used as organic solvents, including aliphatic hydrocarbons, aromatic hydrocarbons, amines, esters, ethers, ketones, and nitrated or chlorinated hydrocarbons.

NIOSHTIC-2 Search

NIOSHTIC-2 is a searchable bibliographic database of occupational safety and health publications, documents, grant reports, and journal articles supported in whole or in part by NIOSH. After clicking on the link above, users can search within the results generated, or create new searches.

NIOSHTIC-2 search results on organic solvents.

NIOSH Publications


Alerts


Alerts briefly present new information about occupational illnesses, injuries, and deaths. Alerts urgently request assistance in preventing, solving, and controlling newly identified occupational hazards.

2-Nitropropane (2-NP)
DHHS (NIOSH) Publication No. 80-142
As a confirmed animal carcinogen, 2-NP has the potential to cause cancer in humans. This document summarizes the cancer studies of 2-NP in laboratory animals and its toxic effects in humans.

Preventing Adverse Health Effects from Exposure to Dimethylformamide (DMF)
DHHS (NIOSH) Publication No. 90-105
This describes engineering controls, good work practices, and personal protective equipment (PPE) recommended for controlling exposures to DMF by inhalation and skin contact.

Preventing Death from Excessive Exposure to Chlorofluorocarbon 113 (CFC-113)
DHHS (NIOSH) Publication No. 89-109
A number of workers have died recently as a result of exposure to CFC-113 in confined spaces or in areas with insufficient ventilation. These workers were apparently unaware that CFC-113 might generate vapor concentrations sufficient to cause death by cardiac arrhythmia or asphyxiation.

Criteria Documents (Criteria for a Recommended Standard)


Criteria documents are developed and recommended by NIOSH for preventing disease and hazardous conditions in the workplace. These documents generally contain a critical review of the scientific and technical information available on the prevalence of hazards, the existence of safety and health risks, and the adequacy of methods to identify and control hazards.

Alkanes (C5-C8)
DHHS (NIOSH) Publication No. 77-151

Benzene
DHHS (NIOSH) Publication No. 74-137

Benzenethiol
DHHS (NIOSH) Publication No. 78-213

Carbon Tetrachloride
DHHS (NIOSH) Publication No. 76-133
(Revised Abstract)
DHHS (NIOSH) Publication No. 76-133r

Chlorobenzene
DHHS (NIOSH) Publication No. 93-102

Chloroform
DHHS (NIOSH) Publication No. [none]

Cyclohexanethiol
DHHS (NIOSH) Publication No. 78-213

2-Diethylaminoethanol
DHHS (NIOSH) Publication No. 96-104

Ethylene Dichloride (1,2-Dichloroethane)
DHHS (NIOSH) Publication No. 78-211

Ethyl Ether
DHHS (NIOSH) Publication No. 93-103

Ethylene Glycol Monobutyl Ether
DHHS (NIOSH) Publication No. 90-118

Ethylene Glycol Monobutyl Acetate
DHHS (NIOSH) Publication No. 90-118

Ethylene Glycol Monoethyl Ether
DHHS (NIOSH) Publication No. 91-119

Ethylene Glycol Monoethyl Ether Acetate
DHHS (NIOSH) Publication No. 91-119

Ethylene Glycol Monomethyl Ether
DHHS (NIOSH) Publication No. 91-119

Ethylene Glycol Monomethyl Ether Acetate
DHHS (NIOSH) Publication No. 91-119

Glycidyl Ethers
DHHS (NIOSH) Publication No. 78-166

Isopropyl Alcohol
DHHS (NIOSH) Publication No. 76-142

Ketones
DHHS (NIOSH) Publication No. 78-173

Metalworking Fluids
DHHS (NIOSH) Publication No. 98-102

Methyl Alcohol
DHHS (NIOSH) Publication No. 76-148

Methylene Chloride
DHHS (NIOSH) Publication No. 76-138

Phenol
DHHS (NIOSH) Publication No. 76-196

Propylene Glycol Ethers and Their Acetates
DHHS (NIOSH) Publication No. 91-103

Refined Petroleum Solvents
DHHS (NIOSH) Publication No. 77-192

1,1,2,2-Tetrachloroethane
DHHS (NIOSH) Publication No. 77-121

Thiols, n-Alkane Mono
DHHS (NIOSH) Publication No. 78-213

Toluene
DHHS (NIOSH) Publication No. 73-11023

1,1,1-Trichloroethane (Methyl Chloroform)
DHHS (NIOSH) Publication No. 76-184

Trichloroethylene
DHHS (NIOSH) Publication No. 73-11025

Xylene
DHHS (NIOSH) Publication No. 75-168

Current Intelligence Bulletins (CIBs)


CIBs review and evaluate new and emerging information about occupational hazards. A CIB may draw attention to a previously unrecognized hazard, report new data on a known hazard, or disseminate information about hazard controls.

Carcinogenic Effects of Exposure to Propylene Oxide —CIB#51

Chloroethanes—CIB#27

Chloroform (DDM)—CIB#9

Ethylene Dibromide and Disulfiram Toxic Interaction—CIB#23

Ethylene Dibromide (EDB)—CIB#3

Ethylene Dibromide (EDB) (Revised) —CIB#37

Ethylene Dichloride (1,2-Dichloroethane) —CIB#25

Glycol Ethers: 2-Methoxyethanol and 2-Ethoxyethanol—CIB#39

Hexamethylphosphoric Triamide (HMPA)—CIB#6

Methylene Chloride —CIB#46

Monohalomethanes: Methyl Chloride CH3Cl, Methyl Bromide CH3Br Methyl Iodide CH3I—CIB#43

2-Nitropropane—CIB#17

Organic Solvent Neurotoxicity—CIB#48

Tetrachloroethylene (Perchloroethylene) —CIB#20

Trichloroethylene (TCE)—CIB#2

Other NIOSH Publications

NIOSH Pocket Guide to Chemical Hazards
DHHS (NIOSH) Publication No. 2005-149
Exposure limits, Respirator Recommendations, First Aid, more...
The NIOSH Pocket Guide is intended as a source of general industrial hygiene information on several hundred chemicals/classes for workers, employers, and occupational health professionals. The NPG does not contain an analysis of all pertinent data, rather it presents key information and data in abbreviated or tabular form for chemicals or substance groupings (e.g. cyanides, fluorides, manganese compounds) that are found in the work environment. The information found in the NPG should help users recognize and control occupational chemical hazards.

Occupational Health Guidelines for Chemical Hazards
DHHS (NIOSH Publications No. 81-123
These guidelines contain technical information about chemical hazards to workers, employers, and safety and health professionals.

Rubber Products Manufacturing Industry: Special NIOSH Hazard Review
DHHS (NIOSH) Publication No. 93-106
Excess deaths from bladder, stomach, lung, hematopoietic, and other cancers have occurred among workers involved in the manufacture of rubber products. These workers may also risk adverse respiratory effects, dermatologic effects, reproductive effects, injuries, and repetitive trauma disorders.

NIOSH Safety and Health Topic Pages


Benzene
2-Butoxyethanol
Carbon Disulfide
Chloroform
1,4-Dioxane
Dimethylformamide
Ethylene Glycol
Methyl Alcohol
Methylene Chloride
Methyl Ethyl Ketone
Phenol
Styrene
Tetrachloroethylene
Toluene
Trichloroethylene
Xylene



Page last updated: August 20, 2009
Page last reviewed: August 20, 2009
Content Source: National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

Organic Solvents

worker on machine/lab bottles/man carrying solvent

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