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Book Review
Molecular Pathogenesis of
Virus Infections
Paul Digard, Anthony A. Nash, and Richard E. Randall, editors
Cambridge University Press, Cambridge, United Kingdom, 2005
ISBN: 0-52-183248-9
Pages: 358, Price: US $125.00
Suggested
citation for this article
Molecular Pathogenesis of Virus Infections describes our current understanding
of the pathogenesis of selected virus and prion infections. The innate
response is an early barrier to virus spread. In this context, O. Haller
et al. describe the antiviral activity of type I interferons and the various
virus-encoded countermeasures. R.P. van Rij and R. Andino review the
role of RNAi as a therapeutic antiviral agent and its use by the host
and virus during viral infections. J.L. Whitton gives an overview of the
adaptive CD8+ T-cell immune response in the context of virus infections.
G. Screaton and J. Mongkolsapaya explain potential roles of T-cell responses
in dengue hemorrhagic fever. E. Turnbull and P. Borrow provide a detailed
description of the ineffectual roles of the innate and immune responses
in the control of HIV and the long road ahead for development of either
a prophylactic or therapeutic vaccine.
Transmissible spongiform encephalopathies have perhaps the most unconventional
natural history of any infectious agent. J.C. Manson and R.M. Barron describe
the diagnosis of transmissible spongiform encephalopathies, the appearance
of new strains, and the nature of host susceptibility to disease. C.M.
Dixon et al. depict the special problems presented to the host by certain
RNA viruses that are maintained and persist in human populations through
avoidance or inhibition of apoptosis, innate immune response, and adaptive
immune response.
Other viruses infect humans only as incidental hosts and cause epizootics
of varying degrees. A.L. Hartman et al. review our current understanding
of the pathogenesis of Ebola and Marburg filoviruses, paying particular
attention to the factors that contribute to lethal disease. C. Dye and
S. Siddell discuss the pathogenesis of feline coronavirus, an animal disease
model that has provided insights into the study of the newly recognized
disease, severe acute respiratory syndrome. R.G. Webster et al. enumerate
the key influenza genes responsible for human pathogenicity, their roles
in past pandemics, and the potential of avian influenza virus strains
to evolve into highly pathogenic and transmissible viruses for human populations.
Many viruses modify host metabolism and innate/immune responses to their
own ends. L. Gray et al. describe the impact of human papillomaviruses
on cell cycle and apoptosis. S.M. Lemon and K. Li review the data documenting
hepatitis C virus disruption of innate intracellular antiviral defenses,
including interferons and toll-like receptors. M.B. Ruiz-Arguello et al.
enumerate the multiple, distinct receptor homologs and binding proteins
encoded by poxviruses that target tumor necrosis factor. L.K. Dixon summarizes
the multiple host pathways that are targeted at multiple levels by African
swine fever virus. J.P. Stewart et al. describe the pathogenesis of murid
herpesvirus 4 that supports its use as model for gammaherpesviruses. M.L.
Freeman et al. provide an overview of the potential role of the immune
system in the latency of the alphaherpesvirus, herpes simplex virus 1.
This book is suitable for the serious student and professional and is
well referenced for further reading.
Robert Buller*
*St. Louis University, St. Louis, Missouri, USA
Suggested citation
for this article:
Buller R. Molecular
pathogenesis of virus infections [book review]. Emerg Infect Dis [serial
on the Internet]. 2006 Jan [date cited]. Available from http://www.cdc.gov/ncidod/EID/vol12no01/05-1305.htm
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