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CD8 hyperlymphocytosis in 17 HIV patients.

Coutellier A, Autran B, Cherin P, Debre P, Herson S; International Conference on AIDS.

Int Conf AIDS. 1994 Aug 7-12; 10: 150 (abstract no. PB0025).

Sce de Medecine Interne, G.H. Pitie Salpetriere, Paris, France.

A CD8 hyperlymphocytosis is observed in 5 to 10% of HIV infected patients. It has been related to a diffuse visceral infiltration: The SICCA syndromee whose clinical observation can be compared to the Gougerot-Sjogren one. Its pronostic value is not clearly established. Seventeen HIV 1 seropositive patients (15 male and 2 female) showing a persistant CD8 hyperlymphocytis (more than 1200/mm3 circulating CD8 rate during more than 3 months) have been studied. 7 patients presented an opportunist infection in spite of high CD4 rates (> 400/mm3). The research of a CD8 visceral infiltration by salivary glands biopsy ocular examination, and broncho-alveolar lavage, was done in 5 patients. No infiltration syndrome has been found. Only one patient showed a CD8 lymphocytary alveolite without phenotypic particularity. The blood lymphocytes phenotypes of 17 patients were studied. In CD4 population there is an imbalance between the CD4 + CD45RA + (memory cells) which have increased and the CD4 + CD45RA +C (virgin cells) which have decreased. In CD8 population, we found an hyperactivation similar the one existing in seropositive patients without CD8 hyperlymphocytosis. The dosage of interleukines IL2, IL4, IL6, TNF alpha and gamma interferon, done in 6 patients is normal. The study of the lymphocytes function effected in 5 patients shows an absence or diminution of the T proliferative response to soluble tuberculine; streptococcic and CMV antigenes and to Pokeweed Mitogen (PKW) constrasting with the persistance of responses to MLR and PHA. In conclusion: The existence of a major CD8 hyperlymphocytosis is not always correlated to the existence of a visceral CD8 infiltration syndrome. CD8 hyperlymphocytis seems to be at the origine of an imbalance of the different CD4 sub-population with an increase of the memory cells and a functionnel deficit to the T proliferative response, responsible for an actual immunodepression not correlated to the CD4 numbers. The HIV patients with CD8 hyperlymphocytose may show opportunist infections as a result of the functional deficit of the auxillary T cells independantly from the absolute CD4 number and this must raise the question of the indication of an antiretroviral treatment.

Publication Types:
  • Meeting Abstracts
Keywords:
  • AIDS Vaccines
  • Acquired Immunodeficiency Syndrome
  • Antigens, CD4
  • Antigens, CD45
  • Antigens, CD8
  • Cell Adhesion Molecules
  • Female
  • HIV Infections
  • HIV Seropositivity
  • HIV-1
  • Humans
  • Male
  • Pokeweed Mitogens
  • T-Lymphocytes
  • immunology
Other ID:
  • 94369461
UI: 102208287

From Meeting Abstracts




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