2004
- 2005 Publications > Molecular
Genetics of Host Response to HIV and HCV
Molecular Genetics of Host Response to HIV and HCV
- The virion infectivity factor (Vif) accessory protein of HIV-1 forms
a complex with the cellular cytidine deaminase APOBEC3G (apolipoprotein
B mRNA-editing enzyme, catalytic polypeptide-like 3G) to block its
antiviral activity. The ability of Vif to block this activity is species-specific. Landau
et al (Salk) reports that A single amino acid of APOBEC3G controls
its species-specific interaction with virion infectivity factor (Vif).Schrofelbauer
et al Proc
Natl Acad Sci U S A. 2004 Mar 16;101(11):3927-32
- One of the major host factors used to fight hepatitis C and other
viral infection are interferons. Katze et al (U Washington) using
aystem-based proteomic analysis of the interferon response in human
liver cells have identified new novel cell adhesion proteins, LAMB1
and ADRM, to be induced by interferon. Genome
Biol. 2004; 5(8):R54
- Smith et al have identified a gene expression profile from
liver biopsies that predicts rapid progression to cirrhosis in liver
transplant patients. Gastroenterology. 2006
Jan;130(1):179-87
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