2004
- 2005 Publications >
Genetics of drug abuse and addiction vulnerability
Genetics of drug abuse and addiction vulnerability
- The Crowley Lab previously reported a linkage for drug dependence
on chromosomal regions (3q24-3q25 and 9q34). Stallings et al now
report that there is linkage on the same chromosomal regions (3q24-3q25
and 9q34) for conduct disorder. A composite of conduct
disorder and drug dependence gives the largest LOD score or 2.65 on
9q34. Crowley suggests that gene in this area mediate vulnerability
to drug dependence and conduct disorder. Arch
Gen Psychiatry. 2005 Sep;62(9):1042-51
- Failure to read by the 3rd grade is a large risk factor for drug
abuse. 3% of the U.S. population is illiterate. Meng et
al identified DCDC2 (doublecortin domain containing 2) on human chromosome
6 as the candidate gene for dyslexia. Proc
Natl Acad Sci U S A. 2005, 102(47):17053-8.
- Correcting for gene stratification ADH4 (alcohol dehydrogenase 4)
is associated with alcohol and drug dependence in European American
but not in African American. Luo et al Neuropsychopharmacology.
2005 Oct 12; and Luo et al. Pharmacogenet
Genomics. 2005 Nov;15(11):755-68.
- Luo et ale confirmed the results of Bierut and colleagues that CHRM2
gene predisposes to alcohol dependence, drug dependence and affective
disorders. Hum
Mol Genet. 2005 Aug 15;14(16):2421-34.
- Fine mapping of Chromosome 7 for drug addiction by Ishiguruo et al has
identified NrCAM haplotypes a being associated with substance abuse
vulnerability. Expression of NrCAM is regulated by drugs of abuse;
it shows allele specific gene expression in post-mortem tissue; and
the knockout of NrCAM reduces conditioned place preference to
opiates and psychostimulants. Neuropsychopharmacology.
2005 Aug 10.
- Using Pooled Genome Wide Association Scanning Liu et al identified
38 loci containing SNPs that display robust allele frequency differences
between abusers and controls in both European- and African-American
samples. These loci identify an alcohol/acetaldehyde dehydrogenase
gene cluster and genes implicated in cellular signaling, gene regulation,
development, "cell adhesion," and Mendelian disorders. The
results converge with previous linkage and association results for
addictions. Proc
Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9.
- Lin et al have identified a coding region polymorphism in the 5HT2B
receptor gene that is associated with vulnerability to illicit drug
abuse. Pharmacogenetics.
2004 Dec;14(12):805-11
- Rates of specific drug disorders (coc, mj, op, sed, stim, tob) elevated
among relatives of alcohol-dependent probands, suggesting shared familial
vulnerability. Nurnberger et al Arch
Gen Psychiatry, 2004, 61: 1246-56
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