Bioinformatics Tools

The National Center for Toxicological Research conducts research in bioinformatics and chemoinformatics and develops and coordinates bioinformatics capabilities within NCTR, across FDA Centers, and in the larger toxicology community. Bioinformatic tools created at NCTR with the goal to develop methods for the analysis and integration of omics (genomics, transcriptomics, proteomics, and metabolomics) datasets include:

• ArrayTrack™
  DNA microarray data management, mining, analysis, and interpretation software
• Decision Forest
  Novel pattern-recognition method for analysis of data from microarray experiments, proteomics research, and predictive toxicology
• Endocrine Disruptor Knowledge Base (EDKB)
  Scientific resources to predict estrogen and androgen activity
• MicroArray Quality Control (MAQC)
  Project to develop microarray quality control metrics and thresholds
• Mold2 
  Software that generates molecular descriptors from two-dimensional structures