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Figure 1. Potential Benefits of Hormone Replacement Therapy. Analytic Framework 1

Analytic Framework 1 begins with 'Postmenopausal women' on the left. A line labeled 'HRT *estrogen, *estrogen/progestin' leads from 'Postmenopausal women' and divides into numbered arrows, each representing a key question: 1. Reduction of coronary heart disease/cardiovascular; 3. Reduction of stroke; 5. Reduction of colorectal cancer; 6. Improvement/ stabalization of bone density disease--a arrow leads from 6. to 7. Reduction of fractures;  8. Improvement/stabalization of cognitive function; 9. Reduction of dementia. Arrows labeled 2 and 4 lead from 1 and 3 respectively to a box that reads 'Reduction in morbidity and mortality'; dotted lines from 5, 7, 8, and 9 also lead to this box.  A wavy arrow leads down from 'HRT *estrogen, *estrogen/progestin' to an oval that reads 'Adverse effects (Analytic Framework 2)'.

Select for Analytic Framework 2 for potential harms.

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