Structural and Digital Biology of Macromolecular Complexes |
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| Launch in standalone player | |
| Air date: | Wednesday, March 31, 2004, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | A typical biological process involves tens to hundreds of proteins to act in coordinated and concerted manner. Understanding their mechanism of actions requires the 3-dimensional photos of the complex at different physiological stages. This spatial and temporal information is critical for designing new therapeutic strategy to prevent or cure diseases.
Typically a macromolecular complex has a molecular size close to or over one million Daltons. A hybrid of technologies in structural and digital biology is necessary to determine the structures of macromolecular complexes. This lecture will illustrate the combined use of electron cryomicroscopy, x-ray crystallography, bioinformatics and structural prediction to study a variety of macromolecular complexes including
viruses, ion channels and machines.
Wah Chiu The NIH Director's Wednesday Afternoon Lecture Series |
| Author: | Wah Chiu, Ph.D., Baylor College of Medicine |
| Runtime: | 90 minutes |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 11947 |
| CIT Live ID: | 2621 |
| Permanent link: | http://videocast.nih.gov/launch.asp?11947 |