Messenger Molecules of Life and Death |
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| Air date: | Wednesday, September 14, 2005, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | We have elucidated a novel apoptotic cascade whereby diverse forms of cell stress activate inducible NO synthase (iNOS). The generated NO nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) abolishing catalytic activity and conferring the ability to bind to Siah. Siah is an ubiquitin-3-ligase which possesses a nuclear localization signal (lacking in GAPDH) and causes the translocation of the two proteins to the nucleus. Within the nucleus GAPDH stabilizes the rapidly turning over Siah. Siah elicits apoptosis by degrading several nuclear proteins.
For more information, visit http://neuroscience.jhu.edu/peopledetail.asp?ID=1 NIH Director's Wednesday Afternoon Lecture Series |
| Author: | Solomon Snyder, M.D., Johns Hopkins School of Medicine |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 12766 |
| CIT Live ID: | 4245 |
| Permanent link: | http://videocast.nih.gov/launch.asp?12766 |