Alternative Splicing in Health and Disease |
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| Launch in standalone player | |
| Air date: | Wednesday, September 07, 2005, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | Talk Summary by Adrian Krainer: I will review basic aspects of how exons and introns are correctly identified and processed by the spliceosome in the context of constitutive and alternative splicing. I will discuss the major determinants of exon identity, and describe experimental approaches to understand how mutations in the coding sequence of genes can lead to aberrant splicing of their transcripts. I will describe a mechanism-based therapeutic approach to correct splicing, using spinal muscular atrophy as an example. Finally, I will describe the involvement of alternative splicing factors in cancer. For more information, visit http://www.cshl.edu/public/SCIENCE/krainer.html The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Adrian Krainer, Ph.D., Cold Spring Harbor Laboratory |
| Runtime: | 75 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 12762 |
| CIT Live ID: | 4243 |
| Permanent link: | http://videocast.nih.gov/launch.asp?12762 |