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Jejunal mucosal morphometry in African patients infected with HIV.

Batman P, Kapembwa M, Sedgwick P, Lucas S, Sewankambo N, Serwadda D, Griffin G; International Conference on AIDS.

Int Conf AIDS. 1991 Jun 16-21; 7: 238 (abstract no. M.B.2226).

St. George's Hospital Medical School, Tooting, London, England

OBJECTIVE: To quantify jejunal morphology in HIV infected African patients. METHODS: Jejunal biopsies were taken by Crosby capsule from 16 HIV positive Ugandan patients (H) (6 AIDS-related complex, 10 AIDS) and 7 Ugandan HIV negative control subjects (C). Biopsies were fixed in formalin, processed to paraffin wax, and serial sections stained with haematoxylin and eosin. Surface area/volume ratio (SV) was estimated using a Weibel eyepiece graticule under light microscopic examination. An estimate of crypt length in each biopsy was obtained by calculating the mean number of enterocyte nuclei along one side of 50 crypts. These sections were also examined for enteric pathogens. RESULTS: There was no significant difference in SV between HIV+ and HIV- subjects (SVH 35.06 +/- 10.91, SVC 35.86 +/- 9.53; mean +/- SD). There was no significant difference in CL between HIV+ and HIV- subjects (CLH37.94 +/- 7.59, CLC 37.29 +/- 4.89; mean +/- SD). In both the HIV+ and HIV- subjects, an inverse relationship was exhibited between SV and Cl (H:r=07.2, gradient = 1.03; Cir = 0.64, gradient = 1.245; SV regressed against CL). Pathogens were found in 3 patients with AIDS (cryptosporidia 1, cryptosporidia with microsporidia 1, strongyloides 1) & in 1 controls (spirochaetosis 1, schistosoma mansoni 1). CONCLUSION: HIV infection has no quantitative effect on jejunal villous surface area and crypt length in Ugandan patients but these biopsies show crypt hyperplastic villous atrophy.

Publication Types:
  • Meeting Abstracts
  • AIDS Vaccines
  • AIDS-Related Complex
  • Acquired Immunodeficiency Syndrome
  • Biopsy
  • HIV
  • HIV Core Protein p24
  • HIV Envelope Protein gp41
  • HIV Infections
  • HIV Seropositivity
  • Humans
  • Intestinal Diseases
  • Intestinal Mucosa
  • Jejunum
  • Microscopy, Electron
  • Mucous Membrane
  • immunology
Other ID:
  • 1222691
UI: 102183149

From Meeting Abstracts

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