Dubois V, Barbeau P, Lafon ME, Pellegrin JL, Fleury H.
J Neurovirol. 1998 Jun 3-6; 4: 347.
Virology Laboratory, University Bordeaux, France.
Our aim was to investigate the presence of JCV DNA and mRNAs (synonyms of JCV active multiplication) in samples taken over 18 months from a PML patient receiving active anti-retroviral treatment. In July [correction of july] 1996, patient GS had been infected with HIV for over 5 years. HIV-1 p24 antigen was detectable in plasma (165 pg/ml). PML was diagnosed on clinical features, characteristic MRI and positive JCV DNA PCR in CSF. Combined 3TC-D4T and Indinavir were started. Blood and urinary samples were tested for JCV T DNA and JCV VP1 mRNAs, initially (MO) and after 4, 12 and 18 months (J Clin Microbiol, 1997; 35 : 228-2292; J Infect Dis, 1998 ; in press.) At M18, patient GS presents limited neurological impairment, stabilized MRI lesions and undetectable HIV-1 plasma load. (Table: see text) JCV active multiplication (mRNA+) was detected only in the initial CSF and in urine. Detailed data, JCV quantification and genotyping will be presented.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- DNA
- DNA Primers
- DNA, Viral
- HIV Infections
- HIV Seropositivity
- Humans
- Polymerase Chain Reaction
- RNA, Messenger
Other ID:
UI: 102237394
From Meeting Abstracts