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JCV DNA and mRNA sequential detection in a patient presenting long term remission of PML. Neuroscience of HIV Infection.

Dubois V, Barbeau P, Lafon ME, Pellegrin JL, Fleury H.

J Neurovirol. 1998 Jun 3-6; 4: 347.

Virology Laboratory, University Bordeaux, France.

Our aim was to investigate the presence of JCV DNA and mRNAs (synonyms of JCV active multiplication) in samples taken over 18 months from a PML patient receiving active anti-retroviral treatment. In July [correction of july] 1996, patient GS had been infected with HIV for over 5 years. HIV-1 p24 antigen was detectable in plasma (165 pg/ml). PML was diagnosed on clinical features, characteristic MRI and positive JCV DNA PCR in CSF. Combined 3TC-D4T and Indinavir were started. Blood and urinary samples were tested for JCV T DNA and JCV VP1 mRNAs, initially (MO) and after 4, 12 and 18 months (J Clin Microbiol, 1997; 35 : 228-2292; J Infect Dis, 1998 ; in press.) At M18, patient GS presents limited neurological impairment, stabilized MRI lesions and undetectable HIV-1 plasma load. (Table: see text) JCV active multiplication (mRNA+) was detected only in the initial CSF and in urine. Detailed data, JCV quantification and genotyping will be presented.

Publication Types:
  • Meeting Abstracts
  • Acquired Immunodeficiency Syndrome
  • DNA
  • DNA Primers
  • DNA, Viral
  • HIV Infections
  • HIV Seropositivity
  • Humans
  • Polymerase Chain Reaction
  • RNA, Messenger
Other ID:
  • 99930700
UI: 102237394

From Meeting Abstracts

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