Latif A, Houston S, Neill P, Bassett M, Thornton C, Sitima J; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 270 (abstract no. M.B.P.289).
University of Zimbabwe Medical School, Zimbabwe
OBJECTIVE: To study the clinical features and response to treatment of KS in patients with HIV infection. METHODS: All patients with HIV infection and histologically proven KS were studied. For staging purposes fiberoptic endoscopy was carried out. Patients were treated with combination chemotherapy using actinomycin D, vincristine and bleomycin. RESULTS: 101 (82%) patients were male and 22 (18%) were female. The mean age of males was 34 years and that for females was 31 years. Generalized lymphadenopathy was found in 107 (87%) patients. Skin lesions in the form of nodules, plaques or diffuse infiltration were found in 115 (93%) patients. 6 patients had mucosal lesions of KS, lymphadenopathy but no skin lesions while 2 had only lymphadenopathic KS. Mucosal lesions were found in the buccal cavity (52%), in the nasopharynx (4%), on the conjunctivae (7%), in the bronchi (17%). Two patients had concomitant infection with Pneumocystis carinii. 98 patients were treated and of the 76 evaluated treatment failure occurred in 18 (23%) while partial or complete remission occurred in 58 (77%). The cumulative death rate for a 24 month period was 35.8%. CONCLUSIONS: Patients with AIDS-related KS respond well to chemotherapy with an initial dramatic improvement. However relapses frequently occur. Patients with pulmonary KS have a poorer prognosis.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Bleomycin
- Dactinomycin
- Drug Therapy, Combination
- Female
- HIV Infections
- Humans
- Male
- Sarcoma, Kaposi
- Skin
- Skin Neoplasms
- Treatment Failure
- Vincristine
Other ID:
UI: 102177143
From Meeting Abstracts