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Children’s Environmental Health Center
EPA Grant Number: R831861Center: USC Center for Children’s Environmental Health
Center Director: Gilliland, Frank
Title: Children’s Environmental Health Center
Investigators: Gilliland, Frank , Avol, Edward L. , Berhane, Kiros , Diaz-Sanchez, David , Dubeau, Louis , Froines, John R. , Gauderman, William , Gong, Henry , Hricko, Andrea , Kuenzli, Nino , Linn, William S. , Lurmann, Fred , McConnell, Rob , Peters, John M.
Current Investigators: Gilliland, Frank , Diaz-Sanchez, David , Froines, John R. , Gong, Henry , McConnell, Rob
Institution: University of Southern California , University of California - Los Angeles
Current Institution: University of Southern California
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Amount: $7,181,692
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Health Effects , Children's Health
Description:
Objective:During its first five years, the Children’s Environmental Health Center (CEHC) supported investigations of the roles of the environment and susceptibility in children’s respiratory health. Important contributions were made supporting the growing consensus that current levels of ambient air pollutants and tobacco smoke have substantial adverse effects on children’s respiratory health, especially among susceptible groups. The overall scientific and translational theme of the CEHC renewal application is air pollution, susceptibility, and childhood airway disease. The objectives proposed for the Center’s next five years are: 1) to investigate the role of ambient air pollutants and genetic susceptibility in airway inflammation and in asthma occurrence during childhood; 2) to investigate the mechanism for the modulating effects of ambient air pollutants on allergic inflammation in children; 3) to implement a community-based participatory research program to respond to community concerns about the effects of regional ambient air pollutants and locally emitted fresh vehicle exhaust on early life asthma; 4) to provide a scientific resource for the broader community involved in protecting children’s environmental health.
Approach:In this application, the CEHC offers an innovative program of community-based participatory research, mechanistic and epidemiologic research to fill some pressing research and public health needs. We propose a vigorous outreach and translation effort to ensure that communities, legislators, regulatory agencies, and other groups interested in children’s environmental health are well informed about the evolving science and health impacts on children and communities. Our proposed research program is integrated scientifically by a biological model that hypothesizes that chronic oxidative and nitrosative stress mediate the chronic effects of air pollution on asthma and allergic rhinitis. We have identified six key research and translation questions about the adverse effects of ambient air pollution on children’s airway diseases: 1) Do regional ambient air pollutants such as O3 or locally emitted fresh vehicle exhaust increase the risk of early life asthma? 2) Is chronic airway inflammation a risk factor for new onset asthma? 3) Do ambient air pollutants or locally emitted fresh vehicle exhaust produce chronic airway inflammation? 4) Do levels of expression or polymorphic variants of genes in antioxidant pathways such as GSTM1 confer special airway sensitivity to air pollution? 5) Which pollutants are responsible for the effects we see? 6) Can scientific approaches and translation to the broader community involved in protecting children’s environmental health be enhanced by community-based participatory research approaches? Because the burden of airway disease and the numbers of children exposed to unhealthful air are large and growing, answers to these questions are urgently needed.
Expected Results:The CEHC research program offers a timely opportunity to efficiently answer these key questions using an integrated approach and unique population and exposure assessment resources. Our collaborative multidisciplinary investigative team and strong working relationships with our community research partners, enhance the CEHC’s ability to continue to contribute to understanding the effects of environmental exposures on childhood airway disease and to strengthen public health efforts to protect children.
Journal Articles: 125 Displayed | Download in RIS Format
| Other center views: | All 138 publications | 125 publications in selected types | All 125 journal articles |
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Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. American Journal of Respiratory and Critical Care Medicine 2001;164(11):2067-2072. |
R831861 (2004) R831861 (2005) |
not available |
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Bastain TM, Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Intraindividual reproducibility of nasal allergic responses to diesel exhaust particles indicates a susceptible phenotype. Clinical Immunology 2003;109(2):130-136. |
R831861 (2004) R831861 (2005) |
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Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. Sex specific effects of asthma on pulmonary function in children. American Journal of Respiratory and Critical Care Medicine 2000;162(5):1723-1730. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) |
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Berhane K, Thomas DC. A two-stage model for multiple time series data of counts. Biostatistics 2002;3(1):21-32. |
R831861 (2004) R831861 (2005) |
not available |
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Berhane K, Gauderman W, Stram D, Thomas D. Statistical issues in studies of the long term effects of air pollution: The Southern California Children’s Health Study. Statistical Science 2004;19(3):414-449. |
R831861 (2005) |
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Bernstein JA, Alexis N, Barnes C, Bernstein IL, Bernstein JA, Nel A, Peden D, Diaz-Sanchez D, Tarlo SM, Williams PB. (2004). Health effects of air pollution. Journal of Allergy and Clinical Immunology 114(5):1116-1123. |
R831861 (2004) R831861 (2005) |
not available |
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Cho AK, Di Stefano E, You Y, Rodriquez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR. Determination of four quinones in diesel exhaust particles, SRM 1649a and atmospheric PM2.5. Aerosol Science and Technology 2004;38(Suppl 1):68-81. |
R831861 (2004) R831861 (2005) R827352 (Final) R827352C001 (Final) R827352C009 (Final) R827352C013 (Final) |
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Corren J, Diaz-Sanchez D, Saxon A, Deniz Y, Reimann J, Sinclair D, Davancaze T, Adelman D. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis. Annals of Allergy, Asthma and Immunology 2004;93(3):243-248. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Delfino RJ, Gong H Jr, Linn WS, Pellizzari ED, Hu Y. Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environmental Health Perspectives 2003;111:647-56. |
R831861 (2005) |
not available |
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Delfino RJ, Gong H, Linn WS, Hu Y, Pellizzari ED. Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air. Journal of Exposure Analysis and Environmental Epidemiology 2003;13:348-63. |
R831861 (2005) |
not available |
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Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Current Allergy and Asthma Reports 2003;3(2):146-152. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Diaz-Sanchez D, Riedl M. Diesel effects on human health: a question of stress? American Journal of Physiology—Lung Cellular and Molecular Physiology 2005;289(5):L722-L723. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Diaz-Sanchez D, Rumold R, Gong H Jr. Challenge with environmental tobacco smoke exacerbates allergic airway disease in human beings. Journal of Allergy and Clinical Immunology 2006;118(2):441-446. |
R831861 (2005) |
not available |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R831861 (2005) R831861C001 (2006) R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) R832141 (2006) R832141 (2007) |
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Eiguren-Fernandez A, Miguel AH, Froines JR, Thurairatnam S, Avol EL. Seasonal and spatial variation of polycyclic aromatic hydrocarbons in vapor-phase and PM2.5 in Southern California urban and rural communities. Aerosol Science and Technology 2004;38:447-455. |
R831861 (2005) R827352 (2004) R827352 (Final) R827352C009 (Final) R827352C013 (Final) |
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Enright PL, Linn WS, Avol EL, Margolis HG, Gong H Jr, Peters JM. Quality of spirometry test performance in children and adolescents: experience in a large field study. Chest 2000;118(3):665-671. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC. Diesel exhaust particles suppress in vivo IFN-γ production by inhibiting cytokine effects on NK and NKT cells. Journal of Immunology 2004;172(6):3808-3813. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. Association between air pollution and lung function growth in southern California children. American Journal of Respiratory and Critical Care Medicine 2000;162(4 Pt 1):1383-1390. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C001 (2001) R826708C003 (2001) |
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Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine 2004;351(11):1057-1067. |
R831861 (2004) R831861 (2005) R831861C003 (2005) |
not available |
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Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005;16(6):737-743. |
R831861 (2004) R831861 (2005) R831861C001 (2005) R831861C001 (2006) R831861C003 (2006) R827352 (Final) R827352C007 (Final) R827352C009 (Final) |
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Gauderman WJ. Air pollution and children—An unhealthy mix. New England Journal of Medicine 2006;355:78-79. |
R831861 (2005) |
not available |
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Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. The Lancet 2007;369(9561):571-577. |
R831861 (2005) R831861C001 (2007) R831861C003 (2007) R827352 (Final) R827352C007 (Final) |
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Gauderman WJ, Murcray C, Gilliland F, Conti DV. Testing association between disease and multiple SNPs in a candidate gene. Genetic Epidemiology 2007;31(5):383-395. |
R831861C003 (2007) |
not available |
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Gilliland FD, McConnell R, Peters J, Gong H Jr. A theoretical basis for investigating ambient air pollution and children’s respiratory health. Environmental Health Perspectives 1999;107(Suppl 3):403-407. |
R831861 (2004) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) |
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Gilliland FD, Linn W, Rappaport E, Avol E, Gong H, Peters J. Effect of spirometer temperature on FEV1 in a longitudinal epidemiological study. Occupational and Environmental Medicine 1999;56(10):718-720. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000;55(4):271-276. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) R826708C003 (2000) |
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Gilliland FD, Li Y-F, Peters JM. Effects of low vitamins A, E, and C intake on children's lung function. American Journal of Respiratory and Critical Care Medicine 2001;163(5):A37. |
R831861 (2004) |
not available |
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Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2001;163(2):429-436. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) |
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Gilliland FD, Islam T, Berhane K, McConnell R, Li Y-F, Peters JM. Obesity and asthma incidence in school-aged children: Results from the Children's Health Study. American Journal of Respiratory and Critical Care Medicine 2001;163(5):A37. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology 2001;12(1):43-54. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2001) |
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Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. Dietary magnesium, potassium, sodium, and children’s lung function. American Journal of Epidemiology 2002;155(2):125-131. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (2000) |
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Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2002;166(4):457-463. |
R831861 (2005) |
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Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. American Journal of Respiratory and Critical Care Medicine 2002;166(3):346-351. |
R831861 (2004) R831861 (2005) |
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Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. American Journal of Respiratory and Critical Care Medicine 2002;166(5):710-716. |
R831861 (2005) |
not available |
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Gilliland FD, Berhane KT, Li YF, Gauderman WJ, McConnell R, Peters J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. American Journal of Epidemiology 2003;158(6):576-584. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Salam MT, Li Y-F, Langholz B. Early life risk factors for asthma: Findings from the Children's Health Study. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A831. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Berhane K, Li YF, Rappaport EB, Peters JM. Effects of early onset asthma and in utero exposure to maternal smoking on childhood lung function. American Journal of Respiratory and Critical Care Medicine 2003;167(6):917-924. |
R831861 (2005) |
not available |
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Gilliland FD, Berhane K, Islam T, Wenten M, Rappaport E, Avol E, Gauderman WJ, McConnell R, Peters JM. Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren. American Journal of Epidemiology 2003;157(10):861-869. |
R831861 (2004) R831861 (2005) |
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Gilliland FD, Li Y-F, Tsai W, Dubeau L. GSTP1 and GSTM1 contribute to susceptibility for asthma and wheezing following in utero exposure to tobacco smoke. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A942. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, Avol E, Peters JM. Obesity and the risk of newly diagnosed asthma in school-age children. American Journal of Epidemiology 2003;158(5):406-415. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gilliland FD, Li Y-F, Tsai W, Dubeau L, Avol E, Peters JM. TNFα-308 genotype and ozone effects on asthma and wheezing: Results from the Children's Health Study (CHS). American Journal of Respiratory and Critical Care Medicine 2003;167(7):A580. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Millstein J, Li Y-F, Lurmann F, Margolis H. Effects of prenatal exposure to O3, PM10, NO2, and CO on birth weight in full-term pregnancies. Epidemiology 2004;15(4):S34. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Glutathione-S-Transferase M1 and P1 genotypes protect against xenobiotic enhancement of allergic responses. Lancet 2004;363:119-125. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C002 (Final) |
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Gilliland FD, Islam T, Berhane K, McConnell R, Peters J. Smoking and asthma incidence in school-aged children: Results from the Children's Health Study. American Journal of Respiratory and Critical Care Medicine 2004;169(7):A709. |
R831861 (2004) R831861 (2005) |
not available |
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Gilliland FD, Li YF, Gong H Jr, Diaz-Sanchez D. Glutathione S-Transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. American Journal of Respiratory and Critical Care Medicine 2006;174(12):1335-1341. |
R831861C003 (2007) |
not available |
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Gilliland FD, Islam T, Berhane K, Gauderman WJ, McConnell R, Avol E, Peters JM. Regular smoking and asthma incidence in adolescents. American Journal of Respiratory and Critical Care Medicine 2006;174(10):1094-1100. |
R831861C003 (2007) |
not available |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1442-1454. |
R831861 (2004) R831861 (2005) R831861C001 (2006) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R832139 (2006) R832141 (2006) R832141 (2007) |
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Gong H. Urban air pollution and health inequities: a workshop report. Environmental Health Perspectives 2001;109(Suppl 3):357-374. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Gong H Jr, Linn WS, Sioutas C, Terrell SL, Clark KW, Anderson KR, Terrell LL. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhalation Toxicology 2003;15(4):305-325. |
R831861 (2005) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) |
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Gong H Jr, Linn WS, Terrell SL, Anderson KR, Clark KW, Sioutas C, Cascio WE, Alexis N, Devlin RB. Exposures of elderly volunteers with and without chronic obstructive pulmonary disease (COPD) to concentrated ambient fine particulate pollution. Inhalation Toxicology 2004;16(11-12):731-744. |
R831861 (2005) R827352 (2004) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) |
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Gong H Jr, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhalation Toxicology 2005;17(3):123-132. |
R831861 (2005) R827352 (Final) R827352C012 (Final) R827352C014 (Final) R827999 (Final) |
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Gong Jr H, Linn WS, Terrell SL, Anderson KR, Clark KW. Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulfur dioxide. Chest 2001;119:402-408. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Hall JV, Brajer V, Lurmann F. Economic valuation of ozone-related school absences in the South Coast Air Basin of California. Contemporary Economic Policy 2003;21:407-417. |
R831861 (2004) R831861 (2005) |
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Hricko A. 2004. Problems along the new silk road. Environmental Health Perspectives 112(15): A879. |
R831861 (2004) R831861 (2005) |
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Hricko A. 2006. Ships, trucks, and trains: effects of goods movement on environmental health. (Invited guest editorial). Environmental Health Perspectives 114(4):A204-A205. |
R831861 (2004) R831861 (2005) |
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Islam T, Gauderman JW, Berhane K, McConnell R, Avol E, Peters J, Gilliland FD. Low lung function predicts new onset asthma among children. Proceedings of the American Thoracic Society 2006;3:A153. |
R831861C001 (2006) |
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Islam T, Gauderman WJ, Berhane K, McConnell R, Avol E, Peters JM, Gilliland FD. Relationship between air pollution, lung function and asthma in adolescents. Thorax 2007;62(11):957-963. |
R831861C001 (2007) R831861C003 (2007) |
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Islam T, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD. Ozone, oxidant defense genes, and risk of asthma during adolescence. American Journal of Respiratory and Critical Care Medicine 2008;177(4):388-395. |
R831861C001 (2007) |
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Jerrett M, Arain A, Kanaroglou P, Beckerman B, Potoglou D, Sahsuvaroglu T, Morrison J, Giovis C. A review and evaluation of intraurban air pollution exposure models. Journal of Exposure Analysis and Environmental Epidemiology 2005;15:185-204. |
R831861 (2005) R831845 (2005) |
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Jerrett M, Buzzelli M, Burnett RT, DeLuca PF. Particulate air pollution, social confounders, and mortality in small areas of an industrial city. Social Science & Medicine 2005;60:2845-63. |
R831861 (2005) |
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Jerrett M, Shankardass K, Gauderman J, Berhane K, Kunzli N, Lurmann F, Avol E, Peters J, Gilliland F, Molitor J, Molitor J, McConnell R. Air pollution and asthma incidence in children. Proceedings of the American Thoracic Society 2006;3:A23. |
R831861C003 (2006) |
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Künzli N, Avol E, Gauderman J, Rappaport E, McConnell R, Peters J, Gilliland F. GSTM1 status modifies the effects of wildfire smoke on asthma symptoms. Proceedings of the American Thoracic Society 2006;3:A502. |
R831861C003 (2006) |
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Künzli N, Avol E, Wu J, Gauderman WJ, Rappaport E, Millstein J, Bennion J, McConnell R, Gilliland FD, Berhane K, Lurmann F, Winer A, Peters JM. Health effects of the 2003 southern California wildfire on children. American Journal of Respiratory and Critical Care Medicine 2006;174(11):1221-1228. |
R831861C003 (2007) |
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Kuenzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN. Ambient air pollution and atherosclerosis in Los Angeles. Environmental Health Perspectives 2005;113(2):201-206. |
R831861 (2004) R831861 (2005) |
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Kuenzli N, Millstein J, Avol E, Gauderman J, McConnell R, Gilliland F, Peters J. Effects of the 2003 California wildfires on children's respiratory health. European Respiratory Journal 2005;26(49):A2475. |
R831861 (2004) R831861 (2005) R831861C001 (2006) |
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Kuenzli, N. and C. Schindler (2005). A call for reporting the relevant exposure term in air pollution case-crossover studies. J Environ Community Health 59(6):527-530. |
R831861 (2004) R831861 (2005) |
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Kunzli N, McConnell R, Bates D, Bastain TM, Hricko A, Lurmann F, Avol E, Gilliland FD, Peters JM. Breathless in Los Angeles: The exhausting search for clean air. American Journal of Public Health 2003;93(9):1494-1499. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Kunzli N, Vora H, Gilliland F, Gauderman JW, Lurmann F, Avol E, Thomas D, Peters J. PM2.5 fractions from non-combustion origin are not associated wtih pulmonary growth in children. American Journal of Respiratory and Critical Care Medicine 2004;169(7):A19. |
R831861 (2004) R831861 (2005) |
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Kunzli N, Perez L, Lurmann F, Hricko A, Penfold B, McConnell R. An attributable risk model for exposures assumed to cause both chronic disease and its exacerbations. Epidemiology 2008;19(2):179-185. |
R831861C001 (2007) |
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Li YF, Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. American Journal of Respiratory and Critical Care Medicine 2000;162(6):2097-2104. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2001) R826708C003 (2001) |
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Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Human Genetics 2005;117(5):476-484. |
R831861 (2004) R831861 (2005) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Li Y-F, Tsao Y-H, Wenten MR, Dubeau L, Gilliland FD. Intercellular adhesion molecule 1 haplotypes and childhood asthma risk. American Journal of Respiratory and Critical Care Medicine 2004;169(7):A583. |
R831861 (2004) R831861 (2005) |
not available |
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Li Y-F, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127:1232-1241. |
R831861 (2004) R831861 (2005) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Li Y-F, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. American Journal of Respiratory and Critical Care Medicine 2006;173(9):970-976. |
R831861 (2004) R831861 (2005) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Linn WS, Avila M, Gong H Jr. Exhaled nitric oxide: sources of error in offline measurement. Archives of Environmental Health 2004;59(8):385-391. |
R831861 (2005) R827352 (Final) R827352C011 (Final) R827352C012 (Final) |
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Lu R, Wu J, Turco RP, Winer AM, Atkinson R, Arey J, Paulson SE, Lurmann FW, Miguel AH, Eiguren-Fernandez A. Naphthalene distributions and human exposure in Southern California. Atmospheric Environment 2005;39:489-507. |
R831861 (2004) R831861 (2005) R827352 (2004) R827352 (Final) R827352C013 (Final) R827352C015 (Final) |
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McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. Air pollution and bronchitic symptoms in Southern California children with asthma. Environmental Health Perspectives 1999;107(9):757-760. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (2000) |
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McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: A cohort study. Lancet 2002;359(9304):386-391. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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McConnell R, Jones C, Avol E, Cozen W, Milam J, Cahero J, Richardson J. Cockroach allergen intervention: some considerations for intervention and exposure assessment. Epidemiology 2002;13(4):S135. |
R831861 (2004) R831861 (2005) |
not available |
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McConnell R, Berhane K, Lurmann F, Molitor J, Gauderman WJ, Avol E, Rappaport E, Gilliland FD, Peters JM. Traffic and asthma prevalence in children. American Journal of Respiratory and Critical Care Medicine 2002;165(8):A492. |
R831861 (2004) R831861 (2005) |
not available |
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McConnell R, Jones C, Milam J, Gonzalez P, Berhane K, Clement L, Richardson J, Hanley-Lopez J, Kwong K, Maalouf N, Galvan J, Platts-Mills T. Cockroach counts and house dust allergen concentrations after professional cockroach control and cleaning. Annals of Allergy, Asthma & Immunology 2003;91(6):546-552. |
R831861 (2004) R831861 (2005) R827352 (2004) R827352 (Final) R827352C007 (Final) |
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McConnell R, Berhane K, Gilliland FD, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) R827352 (2004) R827352 (Final) R827352C007 (Final) R827352C009 (Final) |
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McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K. Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study. Clinical & Experimental Allergy 2005;35(4):426-433. |
R831861 (2004) R831861 (2005) R831861C001 (2005) R831861C001 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C003 (Final) |
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McConnell R, Berhane K, Molitor J, Gilliland F, Künzli N, Thorne P, Thomas D, Gauderman J, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. |
R831861 (2005) R831861C003 (2007) R827352 (Final) R827352C007 (Final) |
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McConnell R, Berhane K, Yao L, Lurmann FW, Avol E, Peters JM. Predicting residential ozone deficits from nearby traffic. Science of the Total Environment 2006;363(1-3):166-174. |
R831861 (2004) R831861 (2005) R831861C001 (2005) R831861C001 (2006) R827352 (Final) R827352C007 (Final) |
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McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. |
R831861 (2004) R831861 (2005) R831861C001 (2006) R831861C003 (2006) R831861C003 (2007) R827352 (Final) R827352C007 (Final) |
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McConnell R, Islam T, Berhane K, Lurmann F, Yao L, Jerrett M, Gauderman J, Gilliland F, Avol E, Thomas D, Peters J. Childhood incident asthma and traffic-related pollution in a longitudinal cohort study. Proceedings of the American Thoracic Society 2007;175:A304. |
R831861C001 (2007) |
not available |
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Millstein J, Gilliland F, Berhane K, Gauderman WJ, McConnell R, Avol E, Rappaport EB, Peters JM. Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study. Archives of Environmental Health 2004;59(10):505-514. |
R831861C003 (2006) |
not available |
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Millstein J, Siegmund K, Conti DV, Gauderman WJ. Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. BMC Genetics 2005;6(Suppl 1):S147. |
R831861 (2004) R831861 (2005) |
not available |
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Millstein J, Siegmund KD, Conti DV, Gauderman WJ. Testing association and linkage using affected-sib-parent study designs. Genetic Epidemiology 2005;29(3):225-233. |
R831861 (2004) R831861 (2005) |
not available |
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Millstein J, Conti DV, Gilliland FD, Gauderman WJ. A testing framework for identifying susceptibility genes in the presence of epistasis. American Journal of Human Genetics 2006;78(1):15-27. |
R831861 (2004) R831861 (2005) R831861C003 (2006) |
not available |
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Mirabelli M, Künzli N, Avol E, Gilliland F, Gauderman J, McConnell R, Rappaport E, Peters J. Increased susceptibility to wildfire smoke among children with small airways. Proceedings of the American Thoracic Society 2007;175:A829. |
R831861C001 (2007) |
not available |
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Molitor J, Molitor N-T, Jerrett M, McConnell R, Gauderman WJ, Berhane K, Thomas D. Bayesian modeling of air pollution health effects with missing exposure data. American Journal of Epidemiology 2006;164(1):69-76. |
R831861 (2005) R831845 (2005) |
not available |
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Molitor J, Jerrett M, Chang CC, Molitor NT, Gauderman J, Berhane K, McConnell R, Lurmann F, Wu J, Winer A, Thomas D. Assessing uncertainty in spatial exposure models for air pollution health effects assessment. Environmental Health Perspectives 2007;115(8):1147-1153. |
R831861C001 (2007) |
not available |
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Perez L, Künzli N, Lurmann F, Avol E, Hricko A, McConnell R. Asthma in children: Burden of air pollution and traffic revisited. Proceedings of the American Thoracic Society 2007;175:A539. |
R831861C001 (2007) |
not available |
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Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. American Journal of Respiratory and Critical Care Medicine 1999;159(3):760-767. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong H Jr, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. American Journal of Respiratory and Critical Care Medicine 1999;159(3):768-775. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Peters JM, McConnell R, Berhane K, Millstein J, Lurmann F, Gauderman J, Avol E, Gilliland FD, Thomas D. Air pollution and the incidence, prevalence and severity of childhood asthma: Results from the southern California Children's Health Study. Epidemiology 2002;13(4):S132. |
R831861 (2004) R831861 (2005) |
not available |
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Rappaport EB, Gilliland FD, Linn WS, Gauderman WJ. Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children. Pediatric Pulmonology 2002;34(2):112-121. |
R831861 (2005) |
not available |
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Richardson JL, Milam JE, Galvan J, Jones C, McConnell R. Knowledge of skin test results among parents of asthmatic children. Journal of Asthma 2005;41(2):199-204. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Riedl MA, Landaw EM, Saxon A, Diaz-Sanchez D. Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen. Journal of Immunology 2005;174(11):7440-7445. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. Journal of Allergy and Clinical Immunology 2005;115(2):221-228. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Ross Z, English PB, Scalf R, Gunier R, Smorodinsky S, Wall S, Jerrett M. Nitrogen dioxide prediction in Southern California using land use regression modeling: potential for environmental health analyses. Journal of Exposure Science and Environmental Epidemiology 2006;16(2):106-114. |
R831861 (2005) |
not available |
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Rumold R, Jyrala M, Diaz-Sanchez D. Secondhand smoke induces allergic sensitization in mice. The Journal of Immunology 2001;167(8):4765-4770. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C002 (2001) |
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Salam MT, Gilliland F, Li Y-F, Langholz B. Early life environmental risk factors for asthma: Findings from the Children’s Health Study. Environmental Health Perspectives 2004;112(6):760-765. |
R831861 (2004) R831861 (2005) R831861C001 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Salam MT, Millstein J, Li YF, Lurmann FW, Margolis HG, Gilliland FD. Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children's Health Study. Environment Health Perspectives 2005;113(11):1638-1644. |
R831861 (2004) R831861 (2005) R831861C003 (2006) |
not available |
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Salam MT, Langholz B, Li Y-F, Gilliland FD. Maternal fish consumption during pregnancy and risk of childhood asthma. Journal of Asthma 2005;42(6):513-518. |
R831861 (2004) R831861 (2005) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Salam MT, Wenten M, Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. Journal of Allergy and Clinical Immunology 2006;117(5):1001-1007. |
R831861 (2004) R831861 (2005) |
not available |
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Salam MT, Lin PC, Gauderman WJ, Gilliland F. Genetic polymorphisms in microsomal epoxide hydrolase and childhood asthma. Proceedings of the American Thoracic Society 2006;3:A349. |
R831861 (2005) |
not available |
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Salam MT, Margolis HG, McConnell R, McGregor JA, Avol EL, Gilliland FD. Mode of delivery is associated with asthma and allergy occurrences in children. Annals of Epidemiology 2006;16(5):341-346. |
R831861 (2004) R831861 (2005) R831861C001 (2006) R831861C003 (2006) |
not available |
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Salam MT, Gauderman WJ, McConnell R, Lin PC, Gilliland FD. Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. American Journal of Respiratory and Critical Care Medicine 2007;176(12):1192-1199. |
R831861C001 (2007) R831861C003 (2007) |
not available |
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Salam MT, Gauderman WJ, McConnell R, Lin PC, Wenten M, Gilliland FD. Transforming growth factor-b1, traffic and childhood asthma. Proceedings of the American Thoracic Society 2007;175:A259. |
R831861C001 (2007) |
not available |
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Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nature Immunology 2005;6(3):223-226. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Schlesinger RB, Kuenzli N, Hidy GM, Gotschi T, Jerrett M. The health relevance of ambient particulate matter characteristics: coherence of toxicological and epidemiological inferences. Inhalation Toxicology 2006;18(2):95-125. |
R831861 (2005) R831845 (2005) |
not available |
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Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwarz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health 2007;70(3-4):311-315. |
R831861 (2005) R832417C001 (2007) |
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Thorne PS, Metwali N, Avol E, McConnell R. Evaluation of surface sampling for endotoxin using electrostatic wiping cloths. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A500. |
R831861 (2004) R831861 (2005) |
not available |
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Thorne PS, Metwali N, Avol E, McConnell RS. Surface sampling for endotoxin assessment using electrostatic wiping cloths. Annals of Occupational Hygiene 2005;49(5):401-406. |
R831861 (2004) R831861 (2005) R831861C001 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Wan J, Diaz-Sanchez D. Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. Journal of Immunology 2006;177(5):3477-3483. |
R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American Journal of Respiratory and Critical Care Medicine 2005;172:1563-1568. |
R831861 (2004) R831861 (2005) R831861C003 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Westerdahl D, Fruin SA, Fine PL, Sioutas C. The Los Angeles International Airport as a source of ultrafine particles and other pollutants to nearby communities. Atmospheric Environment 2008;42(13):3143-3155. |
R831861 (2005) R832413 (2007) R832413 (2008) R832413C001 (2007) |
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Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. The Journal of Immunology 2002;168(5):2560-2567. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826708C001 (Final) R826708C002 (Final) R827352 (Final) R827352C002 (Final) |
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Wu J, Lurmann F, Winer A, Lu R, Turco R, Funk TH. Development of an individual exposure model for application to the Southern California Children’s Health Study. Atmospheric Environment 2005;39(2):259-273. |
R831861 (2004) R831861 (2005) R827352 (Final) R827352C015 (Final) R828172 (Final) R831845 (2005) |
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Wu J, Funk T, Lurmann F, Winer A. Improving spatial accuracy of roadway networks and geocoded addresses. Transactions in GIS 2005;9(4):585-601. |
R831861 (2005) R827352 (Final) R827352C015 (Final) R831845 (2005) |
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Xie B, Gilliland FD, Li YF, Rockett HR. Effects of ethnicity, family income, and education on dietary intake among adolescents. Preventive Medicine 2003;36(1):30-40. |
R831861 (2004) R831861 (2005) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) |
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Diaz-Sanchez, D., R. Rumold, and H. Gong. 2002. Controlled second-hand smoke exposure enhances ragweed-induced IgE, Th2 cytokines and histamine production in allergic subjects. Journal of Allergy and Clinical Immunology 109(1):S90. |
R831861 (2004) R831861 (2005) |
not available |
asthma, children, susceptibility, community,
,
HUMAN HEALTH, ENVIRONMENTAL MANAGEMENT, Air, Scientific Discipline, Health, RFA, Health Effects, Risk Assessment, Health Risk Assessment, Children's Health, Biochemistry, Environmental Chemistry, mobile sources, automotive exhaust, engine exhaust, allergen, respiratory problems, children's environmental health, childhood respiratory disease, susceptibility, outreach and education, community-based intervention, airway disease, automotive emissions, ambient particle pollution, asthma, Human Health Risk Assessment
Progress and Final Reports:
2004 Progress Report
2005 Progress Report
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831861C001 Urban Air Pollution and Persistent Early Life Asthma
R831861C002 Pollution-Enhanced Allergic Inflammation and Phase II Enzymes
R831861C003 Air Pollution, Exhaled Breath Markers, and Asthma in Susceptible Children