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2005 Progress Report: Johns Hopkins Center for Childhood Asthma in the Urban Environment
EPA Grant Number: R832139Center: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Center Director: Breysse, Patrick
Title: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Investigators: Breysse, Patrick , Matsui, Elizabet
Current Investigators: Breysse, Patrick
Institution: Johns Hopkins University
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
Project Amount: $4,046,103
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003)
Research Category: Children's Health , Health Effects
Description:
Objective:The objectives of the Center are to: (1) understand how exposures to environmental pollutants and allergens may relate to airway inflammation and respiratory morbidity in children with asthma in the inner city of Baltimore; and (2) develop effective strategies to reduce morbidity by changing these exposures. We proposed to address these goals with four projects:
- “Epidemiology of Susceptibly to Particulates and Allergens in Asthma” (R832139C001; Greg Diette, M.D., M.S.)—This project will examine the relationship of polymorphisms in genes encoding IL13, TLR4, and BADr to susceptibility to home pollutant and allergen exposure in asthmatic and control children.
- “A Randomized Controlled Trial of Behavioral Changes in Home Exposure Control” (R832139C002; Peyton Eggleston, M.D.)—This project will conduct a randomized controlled clinical trial of methods to increase the effectiveness of current intervention methods to reduce hazardous exposures and their adverse health effects.
- “Mechanisms of Particulate-Induced Allergic Asthma” (R832139C003; Marsha Wills-Karp, Ph.D.)—This project will examine the mechanisms by which urban airborne particulate matter (PM) may exacerbate an allergen-driven inflammatory response in the airways.
- “Dendritic Cell Activation by Particulate Matter and Allergen” (R832139C004; Steven Georas, M.D.)—This project will examine the effect of Baltimore ambient particulates on maturation of peripheral blood monocytes to dendritic cells.
The objective of the Community Outreach and Translational Core (COTC) is to create a structure to develop, implement, and evaluate strategies to translate and apply the scientific findings of the Center into information for the public, policymakers, and clinical professionals to use to protect the health of children.
The overall goal of the Exposure Assessment Core (EAC) is to provide a centralized resource for conducting exposure assessment activities related to children’s asthma research. The Core provides input into research design, field sampling equipment, and support and analytical services. The specific objectives of the Core are to: (1) collaborate in the development and conduct of epidemiologic, intervention, and exposure assessment studies; (2) facilitate the development of exposure assessment protocols; (3) provide the infrastructure necessary for conducting detailed exposure assessments; (4) assist in the design of data collection systems and the maintenance of exposure assessment databases; and (5) participate in the preparation of scientific reports and manuscripts.
The overall goal of the Data Management Core (DMC) is to provide research planning, data management, and data analysis support for the Intervention (R832139C002) and Epidemiology (R832139C001) projects.
Progress Summary:Community Advisory Board
The Community Advisory Board continued to participate actively in the Center’s activities. The Board held quarterly meetings to discuss progress in the refunding of the Center. A major activity has been the dissemination of research findings; a first meeting was held with illustrators to create a comic book and with educators to create an elementary school curriculum.
Meetings were held to create reports to the community relating environmental findings to community activities and health. It was decided that these findings would best be presented in the form of a comic book that could be distributed in many settings (health fairs, community formal lectures, school curricula). In addition, elementary school curricula and dramatic skits and plays presented by elementary school children to other children and to parents were considered.
Through the Community Advisory Board, the Center was introduced to a nonprofit organization, Baltimoreans United in Leadership Development (B.U.I.L.D.), engaged in community renewal. B.U.I.L.D. had recently completed a 650 housing unit neighborhood in Baltimore’s Sandtown-Winchester neighborhood and planned a similar project during the next 5 years in the Center’s East Baltimore catchment area. Preliminary meetings established collaborative goals that included home environmental measures in derelict buildings and longitudinal environmental measures in newly occupied B.U.I.L.D. homes. These projects are scheduled to begin in 2006.
The Community Advisory Committee met during the year to consider the Center’s funding issues and to begin planning for a community presentation of study findings. Two formats were chosen: a comic book designed by a local art institution, the Maryland Institute College of Art, which could be handed out at community organizations during presentations by study staff. In addition, a teacher with middle school experience offered to help script skits by elementary school children to present the study findings in an interesting, engaging format.
Administrative Core
The Administrative Core is responsible for fiscal and administrative policy and reports, for scheduling meetings, maintaining records of all Center meetings, arranging meetings, and creating progress reports. This office arranges the biweekly research conferences, as well as meetings of the Outside Advisory Committee, the Internal Advisory Committee, and the Community Advisory Committee. The unit also arranges for Center personnel to attend annual program meetings. The creation of any public communications originates from this office. The newly recruited faculty program is administered through this Core, although the selection of the scientist is conducted by a committee that has no conflict of interest.
Difficulties and Remedial Action. Most activities of the Administrative Core were delayed in Year 2 of the project because of the delay in funding from the sponsors. Full funding for Year 2 was not received until May 2005. During the period until May 2005, the Administrative Core ensured that ongoing projects such as the Epidemiologic Study (R832139C001) were completed, ensured that Center personnel who were considered nonessential were reassigned to other projects, and that those considered essential, such as the DMC and EAC, were supported while the Center’s projects were completed and publications created. Communication with the External Advisory and the Community Advisory Committees was maintained with periodic meetings or written communication so that they were apprised of the Center’s activities and the status of funding. Finally, the research conferences were continued because the cost was minimal, and they contributed to the morale of the Center personnel.
Community Outreach and Translational Core
Center key personnel continued to participate in community outreach and translational education. A report from the Medical Director at the Center of Maternal and Child Health, Maryland Department of Public Health describing current asthma health statistics as well as environmental measures has been widely distributed.
Several members of the Center’s medical staff are actively involved in medical education with local physicians, nurses, and other health care workers. During the past year, these individuals have presented environmental data and recommendations at continuing medical education courses on asthma and have presented at more than 20 staff meetings of local health care providers. Dr. Eggleston will participate in a regional educational meeting on children’s health and the environment to be conducted at the Mid-Atlantic Center for Children’s Health and the Environment located at George Washington University and sponsored by the State of Maryland and U.S. Environmental Protection Agency Region 3.
Dr. Eggleston was appointed to the Maryland Governor’s Children’s Environmental Health and Protection Advisory Council, an advisory committee charged with ensuring that the State environmental protection laws and regulations accounted for children’s environmental health issues. During the past year, the Council continued its review of school’s policies to evaluate and remediate mold in school buildings.
Most activities of the Community Outreach Core were delayed in Year 2 of the project because of the delay in funding from the sponsors. Full funding for Year 2 was not received until May 2005. Communication with the Community Advisory Committees were maintained with periodic meetings or written communication so that they were apprised of the Center’s activities and the status of funding.
Exposure Assessment Core
Collection of Bulk PM. The EAC has negotiated successfully with the Maryland Tunnel Authority to place two cyclone samplers in the air plenum above the two northbound tubes of the Fort McHenry Tunnel. Sample collection has been ongoing for more than 3 months and more than 1g of PM has been collected from each tunnel; PM characterization studies are being planned.
PM collection on the roof of the Johns Hopkins School of Public Health has been ongoing since June 2005. These samples will be characterized and analyzed in the laboratories of Dr. Wills-Karp and Dr. Georas.
The EAC has explored the use of a multistage low volume cyclone cascade system for the collection of size-selected PM samples.
The EAC also is developing a collaboration with the Applied Physics Laboratory to gain access to a multistage sequential drum sampler for possible use in PM characterization in tunnel, homes, and ambient air.
Interaction With the DMC. The EAC continues to work with DMC on the data quality control, data summarization, and manuscript preparation. One manuscript has been published to date.
Interaction With the COTC. The EAC has participated in COC meetings and currently is assisting in the development of strategies for informing the community about results of Center activities conducted under a previous grant (EPA Agreement No. R826724).
Development of New Analytical Methods. A sampling and analytical method for nicotine in hair to be used as a biomarker of environmental tobacco smoke exposure has been developed and is being validated.
Methods for characterization of endotoxin and other biogenic components of settled and airborne PM are being developed.
Data Management Core
In addition to maintenance of the data management system, the DMC has provided data support services for both the epidemiologic and intervention studies, providing interim and final analyses of accumulated data and participating in the preparation of scientific reports and manuscripts.
The DMC holds weekly meetings with investigators and research staff of the Center to present reports of interim analyses, troubleshoot data collection or quality issues, and provide a forum for discussions regarding abstract and manuscript preparation. To help organize conflicting data requests from the numerous manuscripts in preparation, the Core developed and established a written Data Analysis Request and Dataset Request procedure.
In addition to the weekly meetings, the DMC created a tracking/recruiting database for the Epidemiologic Study (R832139C001) to facilitate collection of genetic samples from families that completed the initial protocol 1 to 2 years earlier.
The DMC created a recruiting database and secured human subject approval by the Johns Hopkins Institutional Review Board. This database consisted of the names and demographic data for all families who have participated in studies conducted by the Center investigators, including but not limited to those the intervention and epidemiologic studies described in this report.
The DMC collaborated with the laboratories in the Environmental Core. The allergen support laboratory developed a data collection and management system for allergen data with a data entry system that includes QC features that link data entry from the allergen lab to the study databases. The Environmental Core laboratory developed a data entry system that links data entry from the Environmental Core laboratory to the main study databases. Written procedures were created for each newly developed data entry system or database to be added to the Manual of Procedures.
In addition to supporting the Center activities, the DMC assists the Center investigators with data analysis for two other National Institutes of Health (NIH)-sponsored clinical trials whose aims and activities overlap with those of the Center. These projects include the ICART, a controlled clinical trial of the efficacy of cockroach allergen abatement in inner-city families, and the HOME, a controlled clinical trial of allergen reduction in suburban and inner-city homes. In addition, a combination of NIH and private funding support the DMC assistance in database development, data management, and data analyses for the JAX Cohort study, a prospective cohort study of newly employed laboratory animal workers.
Research Conferences
The Center’s research conferences have been presented throughout the year. In addition to several speakers from the University and from the Center staff, we have invited speakers from other centers and projects to discuss work that related to the Center’s goals.
Future Activities:The Administrative Core will continue to be responsible for fiscal and administrative policy and reports, for calling meetings, for maintaining records of all Center meetings, and for arranging meetings and creating progress reports. This office will arrange the biweekly research conferences, as well as meetings of the Outside Advisory Committee, the Internal Advisory Committee, and the Community Advisory Committee. The unit will continue to arrange for Center personnel to attend annual program meetings. The creation of any public communications will originate from this office. The newly recruited faculty program is administered through this core, although the selection of the scientists is conducted by a committee with no conflicts of interest.
The formats for community presentation of research findings will be completed.
Research projects established in preliminary discussions with B.U.I.L.D. will be developed and carried out in accordance with the Center’s research agenda.
During the coming year, we will recruit a full time Community Outreach Coordinator and will proceed with the activities outlined in our original proposal. These include:
- Continued meetings of the Community Advisory Committee with its full membership. The committee will help recruit the Community Outreach Coordinator, will advise concerning the needs and performance of the school-based asthma education program, and will oversee our involvement with the East Baltimore development initiative. Finally, the committee will continue to serve as a forum for identifying the community’s needs and resources, in addition to advising on our study design.
- School-based asthma education. The Community Outreach Coordinator will continue the school-based asthma self management classes (A+ Asthma Club) in the six elementary schools selected during the past 4 years.
- Facilitation of healthy housing in East Baltimore. The Coordinator will begin to engage B.U.I.L.D., an organization dedicated to the creation of owner occupied low-cost housing in Baltimore. The organization already has succeeded in creating more than 600 units in West Baltimore and is interested in doing the same in East Baltimore; the Center’s role will be as a consultant and resource to this process. Through our own studies, we understand that asthmatic health is adversely affected by water damaged homes and those infested by cockroaches and mice. Through our clinical trial of environmental intervention in asthma, we can provide preliminary recommendations of specific activities to reduce exposures to specific environmental agents that can improve the health of asthmatic patients. We will be able to provide policy planning, free housing inspection and evaluation, and housing advocacy.
- Health fairs. Center personnel will continue to participate in health fairs sponsored by churches, schools, and other community organizations in East Baltimore. The Coordinator will be responsible for coordinating these activities, recruiting Center personnel, arranging for the presence of the Center’s educational poster board, educational brochures, and soliciting donations of peak flow meters and allergen-proof encasings to be distributed at the fairs.
- Community meetings. The Community Outreach Coordinator will be the Center’s representative at local meetings of neighborhood organizations. As the need arises other Center personnel will be called upon to attend these meetings and to participate in faith-based activities relating to asthma care.
- Health care workers educational activities. Center investigators and staff will continue to participate in educational sessions with local health care workers. These usually take the form of continuing medical education lectures presented in events sponsored by the Johns Hopkins medical institutions or by health care organizations. We anticipate that 5-10 events will occur annually.
- Community focus groups. The Center will continue to hold community focus groups to better understand the issues, attitudes, and needs of community members with regard to asthma and local environment. These groups have been organized in the past by staff from the epidemiology component. During the next year, they will be involved only in an advisory capacity.
- The Center in Urban Environmental Health. The Center includes a Community Outreach and Education Program, headed by Michael Trush, Ph.D. Center investigators and staff from the Children’s Center will continue to participate in the Urban Environmental Health Center’s Environmental and Community Health Course for graduate students. We also will participate in the summer institutes and the Earth Day activities.
The DMC will continue its present activities with an emphasis on interactive databases to facilitate the integration of the laboratory support for the Epidemiology and Intervention trial components. In addition, data set preparation and data analysis activities will continue for the Intervention and the Cohort study components.
The EAC will continue its present activities. As the Intervention and Cohort studies progress to completion, we anticipate that the environmental measurement load will decrease and data analysis activities will increase. In addition, we will be assisting in preparing publications of study findings.
Journal Articles: 100 Displayed | Download in RIS Format
| Other center views: | All 103 publications | 103 publications in selected types | All 100 journal articles |
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Alberg AJ, Diette GB, Ford JG. Invited commentary: Attendance and absence as markers of health status—the example of active and passive cigarette smoking. American Journal of Epidemiology 2003;157(10):870-873. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Barekzi E, Roman J, Hise K, Georas S, Steinke JW. Lysophosphatidic Acid Stimulates Inflammatory Cascade in Airway Epithelial Cells. Prostaglandins, Leukotrienes & Essential Fatty Acids 2006;74(6):357-363. |
R832139 (2007) |
not available |
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Barnes KC, Caraballo L, Munoz M, Zambelli-Weiner A, Ehrlich E, Burki M, Jimenez S, Mathias RA, Stockton ML, Deindl P, Mendoza L, Hershey GK, Nickel R, Wills-Karp M. A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations. Clinical and Experimental Allergy 2004;34(5):736-744. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Barnes KC, Grant AV, Gao P. A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes? Current Opinion in Allergy and Clinical Immunology 2005;5(5):379-385. |
R832139 (2006) |
not available |
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Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall DP, Dienger K, Ingersoll RG, Scott AF, Fallin MD, Mathias RA, Beaty TH, Garcia JG, Wills-Karp M. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes and Immunity 2005;15:1-9. |
R832139 (2006) |
not available |
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Barnes KC. Genetic epidemiology of health disparities in allergy and clinical immunology. Journal of Allergy and Clinical Immunology 2006;117(2):243-254. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
not available |
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Barnes KC, Grant A, Gao P, Baltadjieva D, Berg T, Chi P, Zhang S, Zambelli-Weiner A, Ehrlich E, Zardkoohi O, Brummet ME, Stockton M, Watkins T, Gao L, Gittens M, Wills-Karp M, Cheadle C, Beck LA, Beaty TH, Becker KG, Garcia JG, Mathias RA. Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. Journal of Allergy and Clinical Immunology 2006;118(1):70-77. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
not available |
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Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall DP, Dienger K, Ingersoll RG, Scott AF, Fallin MD, Mathias RA, Beaty TH, Garcia JG, Wills-Karp M. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes and Immunity 2006;7(1):27-35. |
R832139 (2007) |
not available |
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Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with Asthma: Genetic Insights. Proceedings of the American Thoracic Society 2007;4(1):58-68. |
R832139 (2007) |
not available |
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Bartlett SJ, Krishnan JA, Riekert KA, Butz AM, Malveaux FJ, Rand CS. Maternal depressive symptoms and adherence to therapy in inner-city children with asthma. Pediatrics 2004;113(2):229-237. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Bollinger ME, Butz A, Mudd K, Hamilton RG. Contamination of nebulizers with environmental allergens. Annals of Allergy Asthma & Immunology 2005;95(5):429-432. |
R832139 (2006) |
not available |
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Breysse PN, Buckley TJ, Williams D, Beck CM, Jo SJ, Merriman B, Kanchanaraksa S, Swartz LJ, Callahan KA, Butz AM, Rand CS, Diette GB, Krishnan JA, Moseley AM, Curtin-Brosnan J, Durkin NB, Eggleston PA. Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore. Environmental Research 2005;98(2):167-176. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C001 (2006) R832139C002 (2004) |
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Butz AM, Riekert KA, Eggleston P, Winkelstein M, Thompson RE, Rand C. Factors associated with preventive asthma care in inner-city children. Clinical Pediatrics 2004;43(8):709-719. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Butz AM, Pham L, Lewis L, Lewis C, Hill K, Walker J, Winkelstein M. Rural Asthma Education: Impact of Parent and Child Intervention. Journal of Asthma 2005;42:813-821. |
R832139 (2006) |
not available |
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Butz AM, Tsoukleris MG, Donithan M, Hsu VD, Zuckerman I, Mudd K, Thompson RE, Rand C, Bollinger ME. Effectiveness of Home Nebulizer Education Intervention in Young Minority Children with Asthma. Archives of Pediatric and Adolescent Medicine 2006;160:622-628. |
R832139 (2007) R832139C002 (2006) R832139C002 (2007) |
not available |
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Butz AM, Walker J, Pulsifer M. Shared Decision Making in Children with Asthma. Pediatric Nursing 2007;33:111-116. |
R832139C002 (2007) |
not available |
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Butz A, Tsoukleris M, Donithan M, Hsu V, Mudd K, Zuckerman I, Bollinger ME. Patterns of inhaled anti-inflammatory medication use in young underserved children with asthma. Pediatrics 2006;118(6):2504-2513. |
R832139 (2007) R832139C002 (2007) |
not available |
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Butz A. Evidence-Based Practice: What is the Evidence for Medication Adherence in Children? Journal of Pediatric Health Care 2006;20(5):338-341. |
R832139 (2007) R832139C002 (2007) |
not available |
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Callahan KA, Eggleston PA, Rand CS, Kanchanaraksa S, Swartz LJ, Wood RA. Knowledge and practice of dust mite control by specialty care. Annals of Allergy, Asthma & Immunology 2003;90(3):302-307. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Cheadle C, Becker KG, Cho-Chung YS, Nesterova M, Watkins T, Wood W 3rd, Prabhu V, Barnes KC. A Rapid Method for Microarray Cross Platform Comparisons using Gene Expression Signatures. Molecular and Cellular Probes 2007;21(1):35-46. |
R832139 (2007) |
not available |
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Chen R, Roman J, Guo J, West E, McDyer J, Williams MA, Georas SN. Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells. Stem Cells and Development 2006;15(6):797-804. |
R832139 (2007) |
not available |
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Diette GB, Krishnan JA, Wolfenden LL, Skinner EA, Steinwachs DM, Wu AW. Relationship of physician estimate of underlying asthma severity to asthma outcomes. Annals of Allergy, Asthma & Immunology 2004;93(6):546-552. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Diette GB, Patino CM, Merriman B, Paulin L, Okelo S, Thompson K, Krishnan JA, Quartey R, Perez-Williams D, Rand C. Patient Factors that Physicians Use to Assign Asthma Treatment. Archives of Internal Medicine 2007;167:1360-1366. |
R832139C001 (2007) |
not available |
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Eggleston PA. Cockroach allergen abatement in inner-city homes. Annals of Allergy, Asthma & Immunology 2003;91(6):512-514. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Eggleston PA. Environmental control for fungal allergen exposure. Current Allergy and Asthma Reports 2003;3(5):424-429. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, Breysse P, Buckley T, Diette G, Merriman B, Krishnan JA. A randomized controlled clinical trial home environmental intervention in inner city asthma. Annals of Allergy, Asthma and Immunology 2005;95:518-524. |
R832139 (2006) R832139C002 (2006) |
not available |
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Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, Breysse P, Buckley T, Diette G, Merriman B, Krishnan JA. Home environmental intervention in inner-city asthma: a randomized controlled clinical trial. Annals of Allergy Asthma & Immunology 2005;95(6):518-524. |
R832139 (2004) R832139 (2005) R832139C001 (2006) R832139C002 (2005) R832139C003 (2005) |
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Eggleston PA. Improving indoor environments: reducing allergen exposures. Journal of Allergy and Clinical Immunology 2005;116(1):122-126. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned from the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R831710 (2004) R831710 (2005) R831861 (2005) R831861C001 (2006) R832141 (2006) R832141 (2007) |
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Ferrari E, Tsay A, Eggleston PA, Spisni A, Chapman MD. Environmental detection of mouse allergen by means of immunoassay for recombinant Mus m 1. Journal of Allergy and Clinical Immunology 2004;114(2):341-346. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson A, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the Myosin Light Chain Kinase Gene that Confer Risk of Severe Sepsis are Associated with a Lower Risk of Asthma. Journal of Allergy and Clinical Immunology 2007;119(5):1111-1118. |
R832139 (2007) |
not available |
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Garg A, Serwint J, Higman S, Kanof A, Schell D, Colon I, Butz A. Self-Efficacy at Smoking Cessation Counseling Parents in Primary Care: An Office-Based Intervention for Pediatricians and Family Physicians. Clinical Pediatrics 2007;46(3):252-257. |
R832139 (2007) R832139C002 (2007) |
not available |
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Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. Lysophosphatidic Acid is Detectable in Human Bronchoalveolar Lavage Fluids at Baseline and Increased After Segmental Allergen Challenge. Clinical & Experimental Allergy 2007;37(3):311-322. |
R832139 (2007) |
not available |
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Georas S, Guo J, De Fanis U, Casolaro V. T-helper type 2 regulation in allergic disease. European Respiratory Journal 2005;26:1119-37. |
R832139 (2006) |
not available |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1442-1454. |
R832139 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R831861C001 (2006) R831861C003 (2006) R832141 (2006) R832141 (2007) |
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Guajardo JR, Schleifer KW, Daines MO, Ruddy RM, Aronow BJ, Wills-Karp M, Hershey GK. Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma. Journal of Allergy and Clinical Immunology 2005;115(2):243-51. |
R832139C003 (2006) |
not available |
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Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB. Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma. The Journal of Laboratory and Clinical Medicine 2005;145(5):263-274. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C001 (2005) |
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Hansel NN, Eggleston PA, Krishnan JA, Curtin-Brosnan J, Rand CS, Patino CM, Diette GB. Asthma-related health status determinants of environmental control practices for inner-city preschool children. Annals of Allergy, Asthma & Immunology 2006;97(3):409-417. |
R832139 (2007) R832139C001 (2007) |
not available |
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Hansel NN, Rand CS, Krishnan J, Okelo S, Breysse P, Eggleston P, Matsui E, Diette GB. Influence of Caregiver's Health Beliefs on their Use of Environmental Control Practices in Homes of Pre-school Children with Asthma. Pediatric Asthma, Allergy & Immunology 2006;19(4)231-242. |
R832139C001 (2007) |
not available |
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Hansel NN and Diette GB. Gene Expression Profiling in Human Asthma. Proceedings of the American Thoracic Society 2007;4(1):32-36. |
R832139 (2007) R832139C001 (2007) |
not available |
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Hawlisch H, Wills-Karp M, Karp CL, Kohl J. The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Molecular Immunology 2004;41(2-3):123-131. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Huang I-C, Frangakis C, Dominici F, Diette GB, Wu AW. Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Services Research 2005;40(1):253-278. |
R832139 (2004) R832139 (2005) R832139C001 (2004) R832139C001 (2006) |
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Huang I, Frangakis C, Dominici F, Diette GB, Wu AW. Applications of a propensity score approach for risk adjustment in profiling multiple physicians groups on asthma care. Health Services Research 2005;40:253-278. |
R832139 (2006) |
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Huang I-C, Dominici F, Frangakis C, Diette GB, Damberg CL, Wu AW. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Medical Decision Making 2005;25(1):20-34. |
R832139 (2004) R832139 (2005) R832139C001 (2005) R832139C001 (2006) |
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Huang I-C, Diette GB, Dominici F, Frangakis C, Wu AW. Variations of physician group profiling indicators for asthma care. The American Journal of Managed Care 2005;11(1):38-44. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R832139 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831709 (2005) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831710C001 (2006) R831710C002 (2006) R831710C004 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Keen JC, Cianferoni A, Florio G, Guo J, Chen R, Roman J, Wills-Karp M, Casolaro V, Georas SN. Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells. Immunology 2006;117(1):29-37. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
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Kohl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. Journal of Clinical Investigation 2006;116(3):783-796. |
R832139C003 (2006) R832139C003 (2007) |
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Kohl J, Wills-Karp M. A dual role for complement in allergic asthma. Current Opinion in Pharmacology 2007;7:283-289. |
R832139C003 (2007) |
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Kohl J, Wills-Karp M. Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Molecular Immunology 2007;44:44-56. |
R832139C003 (2007) |
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Krishnan V, Diette GB, Rand CS, Bilderback AL, Merriman B, Hansel NN, Krishnan JA. Mortality in patients hospitalized for asthma exacerbations in the United States. American Journal of Respiratory and Critical Care Medicine 2006;174(6):633-638. |
R832139 (2007) R832139C001 (2007) |
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Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Kohl J, Belkaid Y, Wills-Karp M. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. Journal of Experimental Medicine 2005;202(11):1549-1561. |
R832139 (2006) R832139C003 (2006) |
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Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, Hamilton RG, Adkinson Jr NF. Adult asthma severity in individuals with a history of childhood asthma. Journal of Allergy and Clinical Immunology 2005;115(1):61-66. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) |
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Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, Adkinson NF Jr. Irreversible lung function deficits in young adults with a history of childhood asthma. Journal of Allergy and Clinical Immunology 2005;116(6):1213-1219. |
R832139 (2006) |
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Mathias RA, Gao P, Goldstein JL, Wilson AF, Pugh EW, Furbert-Harris P, Dunston GM, Malveaux FJ, Togias A, Barnes KC, Beaty TH, Huang S-K. A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genetics 2006;7:38. |
R832139 (2007) |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, Eggleston PA. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. Journal of Allergy and Clinical Immunology 2003;112(1):87-92. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Matsui EC, Krop EJM, Diette GB, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse-specific IgG and IgG4 levels. Annals of Allergy, Asthma & Immunology 2004;93(2):171-178. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Eggleston PA. Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthma. Journal of Allergy and Clinical Immunology 2004;113(5):910-915. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Matsui EC, Simons E, Rand C, Butz A, Buckley TJ, Breysse P, Eggleston PA. Airborne mouse allergen in the homes of inner-city children with asthma. Journal of Allergy and Clinical Immunology 2005;115(2):358-363. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) |
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Matsui EC, Diette GB, Krop EJM, Aalberse RC, Smith AL, Curtin-Brosnan J, Eggleston PA. Mouse allergen-specific immunoglobulin G and Immunoglobulin G4 and allergic symptoms in immunoglobulin E-sensitized laboratory animal workers. Clinical & Experimental Allergy 2005;35:1347-1353. |
R832139 (2006) R832139C001 (2006) |
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Matsui EC, Eggleston PA, Buckley TJ, Krishnan JA, Breysse P, Rand C, Diette GB. Household Mouse Allergen Exposure and Asthma Morbidity in Inner-city Pre-school Children. Annals of Allergy, Asthma & Immunology 2006;97(4):514-520. |
R832139 (2007) R832139C001 (2007) |
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Matsui EC, Diette GB, Krop EJ, Aalberse RC, Smith AL, Eggleston PA. Mouse Allergen-specific IgG4 and Risk of Mouse Skin Test Sensitivity. Clinical and Experimental Allergy 2006;36(8):1097-1103. |
R832139 (2007) R832139C001 (2006) R832139C001 (2007) |
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Matsui EC, Eggleston PA, Breysse PN, Rand CS, Diette GB. Mouse allergen-specific antibody responses in inner-city children with asthma. Journal of Allergy and Clinical Immunology 2007;119(4):910-915. |
R832139 (2007) R832139C001 (2007) |
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Mudd K, Bollinger ME, Hsu VD, Donithan M, Butz A. Pharmacy fill patterns in young urban children with persistent asthma. Journal of Asthma 2006;43(8):597-600. |
R832139 (2007) R832139C002 (2007) |
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Okelo SO, Wu AW, Krishnan JA, Rand CS, Skinner EA, Diette GB. Emotional quality-of-life and outcomes in adolescents with asthma. Journal of Pediatrics 2004;145(4):523-529. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Okelo SO, Wu AW, Merriman B, Krishnan JA, Diette GB. Are Physician Estimates of Asthma Severity Less Accurate in Black than in White Patients? Journal of General Internal Medicine 2007;22(7):976-981. |
R832139 (2007) R832139C001 (2007) |
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Paasche-Orlow MK, Riekert KA, Bilderback A, Chanmugam A, Hill P, Rand CS, Brancati FL, Krishnan JA. Tailored education may reduce health literacy disparities in asthma self-management. American Journal of Respiratory and Critical Care Medicine 2005;172(8):980-986. |
R832139 (2006) |
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Perkins C, Wills-Karp M, Finkelman FD. IL-4 induces IL-13-independent allergic airway inflammation. Journal of Allergy and Clinical Immunology 2006;118:410-419. |
R832139C003 (2007) |
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Perry TT, Wood RA, Matsui EC, Curtin-Brosnan J, Rand C, Eggleston PA. Room-Specific Characteristics of Suburban Homes as Predictors of Indoor Allergen Concentrations. Annals of Allergy, Asthma & Immunology 2006;97(5):628-635. |
R832139 (2007) |
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Perry T, Matsui E, Merriman B, Duong T, Eggleston P. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. Journal of Allergy and Clinical Immunology 2003;112(2):346-352. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Phipatanakul W, Cronin B, Wood RA, Eggleston PA, Shih M-C, Song L, Tachdjian R, Oettgen HC. Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. Annals of Allergy, Asthma & Immunology 2004:92(4):420-425. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, Kleeberger SR, Wills-Karp M, Karron RA. A role for immune complexes in enhanced respiratory syncytial virus disease. Journal of Experimental Medicine 2002;196(6):859-865. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA. Diesel-enriched particulate matter functionally activates human dendritic cells. American Journal of Respiratory Cell and Molecular Biology 2007;37(6):706-719. |
R832139 (2007) |
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Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. Journal of Experimental Medicine 2005;202(1):47-59. |
R832139 (2006) |
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Riekert KA, Butz AM, Eggleston PA, Huss K, Winkelstein M, Rand CS. Caregiver-physician medication concordance and undertreatment of asthma among inner-city children. Pediatrics 2003;111(3):e214-e220. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Rubenfeld J, Guo J, Sookrung N, Chen R, Chaicumpa W, Casolaro V, Zhao Y, Natarajan V, Georas S. Lysophosphatidic Acid Enhances Interleukin-13 Gene Expression and Promoter Activity in T Cells. Lung Cellular and Molecular Physiology 2006;290(1):L66-L74. |
R832139 (2007) |
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Rubinson L, Wu AW, Haponik EF, Diette GB. Why is it that internists do not follow guidelines for preventing intravascular catheter infections? Infection Control and Hospital Epidemiology 2005;26(6):525-533. |
R832139 (2004) R832139 (2005) R832139C001 (2005) |
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Rubinson L, Wu AW, Haponik EF, Diette GB. Why don’t Internists follow clinical practice guidelines for the prevention of intravascular catheter Infections? Infection Control and Hospital Epidemiology 2005;26(6):525-33. |
R832139 (2006) R832139C001 (2006) |
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Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V. Transcriptional Regulation of Lysophosphatidic Acid-Induced Interleukin-8 Expression and Secretion by p38 MAPK and JNK in Human Bronchial Epithelial Cells. Biochemical Journal 2006;393(3):657-668. |
R832139 (2007) |
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Sapkota A, Symons JM, Kleissl J, Wang L, Parlange MB, Ondov J, Breysse PN, Diette GB, Eggleston PA, Buckley TJ. Impact of the 2002 Canadian forest fires on particulate matter air quality in Baltimore city. Environmental Science & Technology 2005;39(1):24-32. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C001 (2005) R832139C001 (2006) |
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Schmier JK, Manjunath R, Halpern MT, Jones ML, Thompson K, Diette GB. The impact of inadequately controlled asthma in urban children on quality of life and productivity. Annals of Allergy, Asthma & Immunology 2007;98(3):245-251. |
R832139C001 (2007) |
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Schweitzer IB, Smith E, Harrison DJ, Myers DD, Eggleston PA, Stockwell JD, Paigen B, Smith AL. Reducing exposure to laboratory animal allergens. Comparative Medicine 2003;53(5):487-492. |
R832139 (2004) R832139 (2005) R832139C002 (2004) |
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Sharma HP, Hansel NN, Matsui EC, Diette GB, Eggleston PA, Breysee PN. Indoor Environmental Influences on Children’s Asthma. Pediatric Clinics of North America 2007;54(1):103-120. |
R832139 (2007) R832139C001 (2007) |
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Simons E, Curtin-Brosnan J, Buckley TJ, Breysse P, Eggleston PA. Indoor Environmental Differences between Inner City and Suburban Homes of Children with Asthma. Journal of Urban Health 2007;84(4):577-590. |
R832139 (2007) |
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Skinner EA, Diette GB, Algatt-Bergstrom PJ, Nguyen TT, Clark RD, Markson LE, Wu AW. The Asthma Therapy Assessment Questionnaire (ATAQ) for children and adolescents. Disease Management 2004;7(4):305-313. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Smith A, Krishnan JA, Bilderback A, Riekert KA, Rand CS, Bartlett SJ. Depressive symptoms and adherence to asthma therapy after hospital discharge. Chest 2006;130(4):1034-1038. |
R832139 (2007) |
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Swartz LJ, Callahan KA, Butz AM, Rand CS, Kanchanaraksa S, Diette GB, Krishnan JA, Breysse PN, Buckley TJ, Mosley AM, Eggleston PA. Methods and issues in conducting a community-based environmental randomized trial. Environmental Research 2004;95(2):156-165. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Walters DM, Breysse PN, Schofield B, Wills-Karp M. Complement factor 3 mediates particulate matter–induced airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):413-418. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Williams MA, Porter M, Roman J, Breysse P, Williams D, Georas SN. Ambient Baltimore Particulate Matter Directs Non-Classical Immune Activation of Human Myeloid Dendritic Cells. Journal of Allergy and Clinical Immunology 2007;119(2):488-497. |
R832139 (2007) R832139C004 (2007) |
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Williams MA, Cheadle C, Watkins T, Killedar S, Tailor A, Barnes K, Georas S. TLR2 and TLR4 are potential biomarkers of environmental particulate matter exposed human myeloid dendritic cells. Biomarker Insights 2007;2:225-239. |
R832139C004 (2007) |
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Williams MC, Georas S. Gene expression patterns and susceptibility to allergic responses. Expert Review of Clinical Immunology 2006;2:59-73. |
R832139 (2006) R832139 (2007) R832139C001 (2007) R832139C004 (2006) |
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Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nature Reviews Genetics 2004;5(5):376-387. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Wills-Karp M, Koehl J. New Insights into the Role of the Complement Pathway in Allergy and Asthma. Current Allergy and Asthma Reports 2005;5(5):362-369. |
R832139C003 (2006) |
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Wills-Karp M. Complement activation pathways: a bridge between innate and adaptive immune responses in asthma. Proceedings of the American Thoracic Society 2007;4:247-251. |
R832139C003 (2007) |
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Winkelstein ML, Quartey R, Pham L, Lewis L, Lewis C, Hill K, Butz A. Asthma Education for Rural School Health Personnel: Resources, Barriers, and Outcomes. Journal of School Nursing 2006;22:170-177. |
R832139C002 (2006) R832139C002 (2007) |
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Wolfenden LL, Diette GB, Krishnan JA, Skinner EA, Steinwachs DM, Wu AW. Lower physician estimate of underlying asthma severity leads to undertreatment. Archives of Internal Medicine 2003;163(2):231-236. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Yurk RA, Diette GB, Skinner EA, Dominici F, Clark RD, Steinwachs DM, Wu AW. Predicting patient-reported asthma outcomes for adults in managed care. The American Journal of Managed Care 2004;10(5):321-328. |
R832139 (2004) R832139 (2005) R832139C001 (2004) |
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Zambelli-Weiner A, Ehrlich E, Stockton ML, Grant AV, Zhang S, Levett PN, Beaty TH, Barnes KC. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. Journal of Allergy and Clinical Immunology 2005;115(6):1203-1209. |
R832139 (2006) |
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Zeldin DC, Eggleston P, Chapman M, Piedimonte G, Renz H, Peden D. How exposures to biologics influence the induction and incidence of asthma. Environmental Health Perspectives 2006;114(4):620-626. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C001 (2007) R832139C002 (2005) R832139C003 (2005) |
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Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V. Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. Journal of Biological Chemistry 2007;282(14):10172-10179. |
R832139 (2007) |
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childhood asthma, inner-city children, polymorphisms, dendritic cells, pollutants, particulate matter, PM, allergens, children’s health,
,
HUMAN HEALTH, Geographic Area, Scientific Discipline, Health, Health Effects, Risk Assessments, Health Risk Assessment, Epidemiology, Biochemistry, Genetics, State, adolescents, Maryland (MD), urban environment, airborne urban contaminants, environmental tobacco smoke, respiratory disease, asthmatic children, ozone, cigarette smoke, children's health, human health risk, air pollution, airway disease, particulate matter, allergic airway disease, asthma, human exposure
Progress and Final Reports:
2004 Progress Report
Original Abstract
2006 Progress Report
2007 Progress Report
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen