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Division of Intramural Research
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Home Research Intramural Research
The Division of Intramural Research
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NHGRI's Division of Intramural Research plans and conducts a broad program of laboratory and clinical research to translate genomic and genetic research into a greater understanding of human genetic disease, and to develop better methods for the detection, prevention and treatment of heritable and genetic disorders. |
News and Events
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 The agent currently used to detect recurrence of thyroid cancer is difficult to produce and must be injected. Researchers at the National Institutes of Health and colleagues in Germany have found a promising alternative that is easy to produce and can be injected or given orally, at least in mice. Co-authors of the paper included Christopher P. Austin, M.D., and James Inglese, Ph.D., from the NIH Chemical Genomics Center, administered by NHGRI. The research was published online (before print) on July 10, 2009 in the Proceedings of the National Academy of Sciences. [ Full Text   ]
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 National Institutes of Health researchers sequenced microbial DNA on healthy individuals to advance new and better strategies for treating and preventing skin diseases. A study published in the May 29, 2009 issue of the journal Science reveals that our skin is home to a much wider array of bacteria than previously thought. [ Full Text]
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 Fulfilling the Promise of a
Sequenced Human Genome
NHGRI Scientific Director Eric Green, M.D., Ph.D.,
delivers the keynote address at the fourth annual Sequencing, Finishing and Analysis in the Future conference held May 27 in Santa Fe, N.M. Dr. Green, also director of the NIH Intramural Sequencing Center, describes the advances in high-throughput genomic sequencing that are revolutionizing science and medicine.
Watch the Video
Part I |
Part II
Video provided by Department of Energy's Joint Genome Institute through www.scivee.tv.
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Research supported in part by NHGRI provides the strongest genomic evidence to date that more males than females participated in the human dispersal out of Africa 60,000 to 100,000 years ago. The finding is based on analysis of very large DNA data sets collected from four geographically diverse populations and compared patterns of genetic variation between the sex chromosome X and the non-sex chromosomes (autosomes). The analysis detected accelerated genetic drift beyond what would be expected on the X chromosome relative to the autosomes. Genetic drift is the tendency over many generations for a chance mutation to become a more common variation within the genome of a species. The significant difference in variation led the authors to conclude that a disproportionately larger number of males than females migrated out of the African continent to establish the founding population which later split into the European and Asian populations. James Mullikin, Ph.D., associateinvestigator, Genome Technology Branch, NHGRI, co-authored the paper with colleagues at the Harvard Medical School and the Broad Institute of Harvard and MIT. "We can now get a better glimpse of the migration patterns during in the African dispersion event(s)," he said, noting that his role included preparing the large datasets while maintaining the fidelity of the underlying signals for the analysis to pick up on these historic events. Accelerated genetic drift on chromosome X during the human dispersal out of Africa is published in the December 21, 2008 advance online issue of the journal Nature Genetics.
[Full Text ]
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News Features from the Division of Intramural Research |
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The 2009 NHGRI Intramural Research Brochure (42Mb)  |
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Division of Intramural Research Tenure Track Positions |
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Current Topics in Genome Analysis 2008 |
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News and Events Archive |
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NHGRI Event Webcasts |
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To view the PDFs on this page you will need Adobe Reader.
Last Updated: July 21, 2009
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Genomics in Action
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K. J. Myung, Ph.D. won't just tell you about unstable genomes, he'll show you one. He studies genome instability, which is both a characteristic of and, in some cases, a trigger for many genetic diseases, including cancer. (more)
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