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What drug treatments are available for MS and its symptoms?
Below is a table of drugs used to treat multiple sclerosis and its symptoms. It only lists drug therapies and does not deal with other forms of therapy - I shall address these in a later section.
The previous section lists the symptoms of multiple sclerosis.
It is vital that you are prescribed and take any of these medications in consultation with a fully qualified medical practioner who is familiar with your case history. Many of these drugs have potentially serious side-effects especially in combination with other medications.
The list is by no means complete and new treatments are being researched and coming into use all the time. It should be emphasised that none of these drugs are a "cure" for either MS nor for any of its symptoms. The only medications available at the moment either slow down the course of the disease at best or are palliative on its symptoms.
Very often, the "manufacturer"
links in the table take you through to the specific manufacturer's data
on each treatment. [The table is still being built and many of the internal
links will take you to a blank page - please bear with me as I complete
this project.]
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Relapsing-Remitting MS, Secondary Progressive MS with relapses | Interferon Beta 1a | 30 mcg intramuscular once per week self-injection | Avonex | Biogen |
44 mcg subcutaneous 3 times per week self-injection | Rebif | Ares-Serono | ||
Interferon Beta 1b | Subcutaneous self-injection once every two days | Betaseron | Berlex | |
Betaferon | Schering | |||
Relapsing-Remitting MS | Glatiramer Acetate | 20mg subcutaneous daily self-injection | Copaxone | Teva-Marion |
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Secondary Progressive MS, Worsening Relapsing-Remitting MS | Mitoxantrone | Intravenous every 3 months for about 2 to 3 years | Novantrone | Immunex |
Potential, unlicensed treatments for Secondary Progressive MS and Worsening Relapsing-Remitting MS | Azathioprine | Anti-cancer treatments - currently unlicensed for use with MS | Imuran | Glaxo-Smith-Kline |
Cyclophosphamide | Anti-cancer treatments - currently unlicensed for use with MS | Cytoxan, Neosar | Bristol-Myers Squibb | |
Cyclosporine | Anti-cancer treatments - currently unlicensed for use with MS | Sandimmune | Novartis Pharma | |
Methotrexate | Anti-cancer treatments - currently unlicensed for use with MS | generic | Mylan | |
Cladribine | Anti-cancer treatments - currently unlicensed for use with MS | Leustatin | ||
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Acute relapses in Relapsing-Remitting MS and occasionally Secondary Progressive MS | MethylPrednisolone | Intravenous high doses tapered off | Depo-Medrol | |
Solu-Medrol | Pharmacia | |||
Prednisone | Oral administration | Deltasone | Pharmacia | |
Prednisolone | Intravenous administration | Delta-Cortef | Pharmacia | |
Dexamethasone
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Oral administration | Medrol | Pharmacia | |
Decadron | Merck | |||
Adreno-corticotrophic Hormone (ACTH), Corticotropin | Use largely replaced by synthetic corticosteroids | Acthar | Roche, Rhone-Poulenc Rorer | |
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Neuropathic/neurogenic pain (pain that arises from nerve dysfunction and not as a result of injury e.g. Trigeminal Neuralgia) | Carbamazepine | Anti-convulsant | Tegretol, Epitol, Atretol, Carbatrol | Ciba |
Gabapentin | Anti-convulsant | Neurontin | Pfizer | |
Topiramate | Anti-convulsant | Topamax | Ortho-McNeil | |
Zonisamide | Anti-convulsant | Zonegran | Elan | |
Phenytoin | Dilantin | |||
Desipramine | Norpramin | |||
Amitriptyline | Tricyclic antidepressant | Elavil | AstraZeneca | |
Imipramine | Tricyclic antidepressant | Tofranil, Imavate, Janimine | Ciba Geigy | |
Doxepin | Tricyclic antidepressant | Sinequan, Adapin, Triadapin, Zonalon | ||
Protriptyline | Tricyclic antidepressant | Vivactil | ||
Cannabis and synthetic cannabinoids | Illegal in many parts of the world | Marinol | ||
Pain associated with poor circulation | Pentoxifylline | Trental | ||
'flu-like
symptoms associated with Beta Interferon injections
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Ibprofen
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Neurofen | ||
US versions | ||||
Aspirin | generic | |||
Acetaminophen | Often formulated with alkaloid pain killers like codeine and hydrocodone | generic | ||
Paroxysmal itching | Hydroxyzine | Atarax | ||
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Depression without anxiety | Fluoxetine | SSRI | Prozac | Eli Lilly |
Mild
anxiety, panic attacks, people on multiple medications
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Sertraline | SSRI
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Zoloft | Pfizer |
Lustral | Pfizer | |||
Moderate depression, anxiety, people for whom other antidepressants don't work | Venlafaxine | SSRI | Effexor XR | Wyeth-Ayerst Laboratories |
Depression with mild anxiety | Citalopram | SSRI | Celexa | Forest Pharmaceuticals |
Depression with mild anxiety | Parocetine | SSRI | Paxil, Seroxat | Glaxo-Smith-Kline |
Depression also agoraphobia, insomnia, essential tremor, some pain syndromes | Trazodone | Similar to SSRIs - works by increasing the amount of serotonin | Desyrel, Trialodine | Pharmacia |
Depression | Amitriptyline | Tricyclic antidepressant | Elavil | AstraZeneca |
Endogenous depression | Nortriptyline | Tricyclic
antidepressant
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Pamelor | Novartis |
Aventyl | Eli Lilly | |||
Depression | Imipramine | Tricyclic antidepressant | Tofranil, Imavate, Janimine | Ciba Geigy |
Depression particularly when accompanied by anxiety and insomnia | Dothiepin | Tricyclic antidepressant | Prothiaden | Knoll Pharmaceuticals |
Depression of varying severity with coexisting anxiety | Lofepramine | Tricyclic antidepressant | Gamanil | Organon |
Anxiety, neurosis, manic depression | Doxepin | Tricyclic antidepressant | Sinequan, Adapin, Triadapin, Zonalon | |
All types of depression, apathety, withdrawl | Protriptyline | Tricyclic antidepressant | Vivactil | |
Moderate to severe depression | Tranylcypromine | Monoamine oxidase inhibitor (MAOI) | Parnate | Glaxo-Smith-Kline |
Depression particularly when accompanied by social phobia | Moclobemide | Monoamine oxidase inhibitor (MAOI) | Manerix, Aurorix | Roche |
Withdrawn, depression-related fatigue, concentration and attention problems, depression-related sexual dysfunction | Bupropion | Aminoketone antidepressant | Wellbutrin SR | Glaxo-Smith-Kline |
Amfebutamone | ||||
Depression with significant anxiety, panic attacks, insomnia, sexual dysfunction | Nefazodone | Phenylpiperazine antidepressant | Serzone | Bristol-Myers Squibb |
Depression with insomnia, moderate to severe anxiety, sexual dysfunction | Mirtazapine | Piperazino-azepine antidepressant | Remeron | Organon |
Insomnia | Zolpidem | Imidazopyridine | Ambien | Pharmacia |
Anxiety - not indicated if primary complaint is depression | Alprazolam | Benzodiazepine - addictive | Xanax | Pharmacia & Upjohn |
Insomnia, Anxiety | Temazepam | Benzodiazepine - addictive | Restoril | Novartis |
Anxiety, Insomnia, muscle relaxant | Diazepam | Benzodiazepine - addictive | Valium | Roche |
Anxiety | Buspirone | Azaspirodecanedione | BuSpar | Bristol-Myers Squibb |
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Multiple sclerosis fatigue. Also dystonia and akathisia | Amantadine | Anti-viral | Symmetrel | Endo Pharmaceuticals |
Fatigue | Pemoline | Central Nervous System stimulant | Cylert | |
Modafinil | Provigil | |||
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Urinary Frequency and Urgency | Oxybutynin | Ditropan XL | ||
Desmopressin, Vasopressin | Nasal spray | DDAVP | ||
Urinary Urgency and Incontinence | Tolterodine | Detrol | ||
Carbamazepine | Anti-convulsant | Tegretol, Epitol, Atretol, Carbatrol | Ciba | |
Imipramine | Tofranil | |||
Bethane | Urecholine | |||
Urinary Hestitancy | Phenoxybenzamine | Dibenzyline | ||
Terazosin | Hytrin | |||
Spastic Bladder | Propantheline | Anticholinergic agent | Pro-Banthine | |
Oxybutynin | Anticholinergic agent | Ditropan | ||
Hyoscyamine | Anticholinergic agent | Urispas | ||
Cystopas | ||||
Baclofen | Sceletal muscle relaxant | Lioresal | ||
Diazepam | Benzodiazepine - addictive | Vallium | ||
Urinary Tract Infections (UTI) | Methenamine | Hiprex | ||
Mandelamine | ||||
Nitrofurantoin | Macrodantin | |||
Phenazopyridine | Pyridium | |||
Ciprofloxacin | Cipro | |||
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Constipation | Bisacodyl | Stimulant
laxative
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Dulcolax | |
Bisacolax | ||||
Magnesium hydroxide (Milk of Magnesia) | Hyperosmotic laxative | generic | ||
Glycerin | Hyperosmotic laxative, suppository | Sani-Supp | ||
Psyllium hydrophilic mucilloid | Bulk-forming oral laxative | Metamucil | ||
Sodium phosphate | Fleet Enema | |||
Docusate | Stool Softener | Colace | ||
Suppository | Therevac Plus | |||
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Erectile dysfunction in men and women | Sildenafil | Viagra | ||
Erectile
dysfunction
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Alprostadil | Suppository | Prostin VR | |
MUSE | ||||
Papaverine | Injection into penis | |||
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Spasticity | Diazepam | Benzodiazepine | Valium | |
Clonazepam | Benzodiazepine | Klonopin | ||
Rivotril | ||||
Baclofen | Sceletal muscle relaxant | Lioresal | ||
Dantrolene sodium | Sceletal muscle relaxant | Dantrium | ||
Tizanidine | Sceletal muscle relaxant | Zanaflex | Elan | |
Sirdalud | ||||
Clonidine | Antihypertensive | Catapres | ||
Botulinum Toxin | Kills Nerves | Botox, Neurobloc | , Elan | |
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Postural
tremor
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Clonazepam | Klonopin | ||
Rivotril | ||||
Gabapentin | Neurontin | |||
Beta blockers | ||||
Primidone | Mysoline | |||
Botulinum toxin | Kills Nerves | |||
Acetazolamide | Diamox | |||
Rest
tremor
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Levodopa­carbidopa | Sinemet | ||
anticholinergics | ||||
Tremor | Isoniazid | Laniazid | ||
Nydrazid | ||||
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Vertigo, Nausea, Dizziness | Meclizine | Antivert | ||
Bonamine | ||||
Dimenhydrinate | Dramamine | |||
Prochlorperazine | Compazine | |||
Scopolamine | Transderm | |||
Diphenhydramine | Benedryl | |||
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Prevention of Relapses | 'flu jabs | Now recommended for people with MS | N/A | N/A |
Acyclovir | ||||
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Relaspsing-Remitting Multiple Sclerosis and possibly Secondary Progressive MS | Natalizumab | Monoclonal antibody - blocks access for lymphocytes to the central nervous system | Antegren | Elan/Biogen |
Relaspsing-Remitting Multiple Sclerosis and Secondary Progressive MS | Alemtuzumab | Monoclonal antibody - kills T Cells | Campath-1H | Schering/Millennium Pharmaceuticals/ILEX Oncology |
4-aminopyridine | Blockspotassium channels in neurons which may improve nerve transmission in MS | Fampridine | Elan/Accorda | |
3,4 Diaminopyridine | Blocks potassium channels in neurons which may improve nerve transmission in MS | |||
Eliprodil | Might promote remyelination | |||
IV Immunoglobin | Reduces severity of viral infections | Gammagard, Gammar-IV, Gamimune N, Iveegam, Panglobulin, Sandoglobulin, Venoglobulin | ||
May reduce severity of relapses | AnergiX-MS | Anergen | ||
Neuropathic pain | Pregabalin | Concerns raised over safety because of tumours in mice | Pfizer | |
Chronic pain | Ziconotide | Non-opioid, calcium channel blocker | Elan/Neurex |